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A TLR7-nanoparticle adjuvant promotes a broad immune response against heterologous strains of influenza and SARS-CoV-2
- Source :
- Nature materials, vol 22, iss 3
- Publication Year :
- 2023
- Publisher :
- eScholarship, University of California, 2023.
-
Abstract
- The ideal vaccine against viruses such as influenza and SARS-CoV-2 must provide a robust, durable and broad immune protection against multiple viral variants. However, antibody responses to current vaccines often lack robust cross-reactivity. Here we describe a polymeric Toll-like receptor 7 agonist nanoparticle (TLR7-NP) adjuvant, which enhances lymph node targeting, and leads to persistent activation of immune cells and broad immune responses. When mixed with alum-adsorbed antigens, this TLR7-NP adjuvant elicits cross-reactive antibodies for both dominant and subdominant epitopes and antigen-specific CD8+ T-cell responses in mice. This TLR7-NP-adjuvanted influenza subunit vaccine successfully protects mice against viral challenge of a different strain. This strategy also enhances the antibody response to a SARS-CoV-2 subunit vaccine against multiple viral variants that have emerged. Moreover, this TLR7-NP augments antigen-specific responses in human tonsil organoids. Overall, we describe a nanoparticle adjuvant to improve immune responses to viral antigens, with promising implications for developing broadly protective vaccines.
- Subjects :
- Subunit
and promotion of well-being
Bioengineering
Vaccine Related
Mice
Immunologic
Biodefense
Animals
Humans
Nanotechnology
General Materials Science
Adjuvants
Nanoscience & Nanotechnology
Lung
Vaccines
SARS-CoV-2
Mechanical Engineering
Prevention
Inflammatory and immune system
Immunity
COVID-19
General Chemistry
Pneumonia
Condensed Matter Physics
Prevention of disease and conditions
Influenza
Infectious Diseases
Emerging Infectious Diseases
Good Health and Well Being
Toll-Like Receptor 7
3.4 Vaccines
Mechanics of Materials
Influenza Vaccines
Pneumonia & Influenza
Nanoparticles
Immunization
Infection
Human
Biotechnology
Subjects
Details
- Database :
- OpenAIRE
- Journal :
- Nature materials, vol 22, iss 3
- Accession number :
- edsair.doi.dedup.....1c9e5a2894f2a6f1915187af816bf497