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Sensorineural Hearing Loss After Teprotumumab Therapy for Thyroid Eye Disease: A Case Report
- Source :
- Otology & Neurotology. 43:e148-e152
- Publication Year :
- 2021
- Publisher :
- Ovid Technologies (Wolters Kluwer Health), 2021.
-
Abstract
- Background and objective Teprotumumab is a fully human IgG1 monoclonal antibody against insulin-like growth factor-1 receptor (IGF-1R). It has been approved by the FDA to treat thyroid eye disease (TED) by reducing extraocular muscle and orbital fat volume. In clinical trials, hearing loss was noted as a side effect in 7 to 12% of patients, but no formal audiometric investigations of these patients were reported. Furthermore, the FDA and manufacturer offer no formal guidelines for audiometric monitoring. This case report is the first to describe sensorineural hearing loss (SNHL) in a patient undergoing treatment with teprotumumab. Patient A 77-year-old woman presenting with bilateral SNHL after treatment with teprotumumab therapy for TED. Intervention Audiometric testing was performed due to worsening and prolonged SNHL after subsequent teprotumumab infusions. Main outcome measures Word recognition scores, pure tone average. Results Audiometry after discontinuation of therapy showed moderate to moderate-severe SNHL with word recognition scores of 64% in the right ear and 68% in the left ear. Conclusions There are currently no formal guidelines for routine audiograms before, during, and after infusion of teprotumumab. Given that such guidelines exist for ototoxic medications such as gentamicin and cisplatin, we strongly encourage audiometric monitoring for patients undergoing treatment with teprotumumab.
- Subjects :
- Pediatrics
medicine.medical_specialty
Side effect
Hearing loss
Hearing Loss, Sensorineural
Eye disease
Antibodies, Monoclonal, Humanized
otorhinolaryngologic diseases
medicine
Humans
Aged
medicine.diagnostic_test
business.industry
Audiogram
medicine.disease
Sensory Systems
Discontinuation
Graves Ophthalmopathy
Clinical trial
Otorhinolaryngology
Female
Sensorineural hearing loss
Neurology (clinical)
medicine.symptom
Audiometry
business
Orbit
Subjects
Details
- ISSN :
- 15374505 and 15317129
- Volume :
- 43
- Database :
- OpenAIRE
- Journal :
- Otology & Neurotology
- Accession number :
- edsair.doi.dedup.....1ca0d444c0fb5a3366233d82d8b2644b