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GutSelf: Inter‐Individual Variability in the Processing of Dietary Compounds by the Human Gastrointestinal Tract
- Source :
- Molecular Nutrition and Food Research, Molecular Nutrition and Food Research, Wiley-VCH Verlag, 2019, 63 (21), pp.1900677. ⟨10.1002/mnfr.201900677⟩, Molecular Nutrition & Food Research
- Publication Year :
- 2019
- Publisher :
- HAL CCSD, 2019.
-
Abstract
- Nutritional research is currently entering the field of personalized nutrition, to a large extent driven by major technological breakthroughs in analytical sciences and biocomputing. An efficient launching of the personalized approach depends on the ability of researchers to comprehensively monitor and characterize interindividual variability in the activity of the human gastrointestinal tract. This information is currently not available in such a form. This review therefore aims at identifying and discussing published data, providing evidence on interindividual variability in the processing of the major nutrients, i.e., protein, fat, carbohydrates, vitamins, and minerals, along the gastrointestinal tract, including oral processing, intestinal digestion, and absorption. Although interindividual variability is not a primary endpoint of most studies identified, a significant number of publications provides a wealth of information on this topic for each category of nutrients. This knowledge remains fragmented, however, and understanding the clinical relevance of most of the interindividual responses to food ingestion described in this review remains unclear. In that regard, this review has identified a gap and sets the base for future research addressing the issue of the interindividual variability in the response of the human organism to the ingestion of foods.<br />Despite numerous examples of interindividual variability in the processing of food by the human gastrointestinal tract, the knowledge on this topic, as illustrated for polymorphisms in mineral absorption, remains fragmented. The GutSelf review sets the base for motivating future research specifically addressing the issue of the interindividual variability in the response of the human organism to the ingestion of foods.
- Subjects :
- 0301 basic medicine
gut microbiome
Review
digestion
Bioinformatics
polymorphism
Clinical endpoint
Ingestion
Amino Acids
2. Zero hunger
Minerals
Gastrointestinal tract
Biological Variation, Individual
nutrition personnalisée
Human gastrointestinal tract
Vitamins
medicine.anatomical_structure
1305 Biotechnology
Dietary Proteins
Biotechnology
610 Medicine & health
Biology
1117 Public Health and Health Services
03 medical and health sciences
Dietary Carbohydrates
medicine
Humans
1106 Food Science
tractus gastrointestinal
Polymorphism, Genetic
030109 nutrition & dietetics
nutriment
Nutrition & Dietetics
Human organism
food
variabilité interindividuelle
Intestinal digestion
10060 Epidemiology, Biostatistics and Prevention Institute (EBPI)
Dietary Fats
Gut microbiome
Gastrointestinal Microbiome
030104 developmental biology
Intestinal Absorption
Personalized nutrition
1111 Nutrition and Dietetics
gastrointestinal tract
[SDV.AEN]Life Sciences [q-bio]/Food and Nutrition
0908 Food Sciences
Peptide Hydrolases
Food Science
Subjects
Details
- Language :
- English
- ISSN :
- 16134125 and 16134133
- Database :
- OpenAIRE
- Journal :
- Molecular Nutrition and Food Research, Molecular Nutrition and Food Research, Wiley-VCH Verlag, 2019, 63 (21), pp.1900677. ⟨10.1002/mnfr.201900677⟩, Molecular Nutrition & Food Research
- Accession number :
- edsair.doi.dedup.....1cad09d3d721a7c43f282027f6ab8398