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Urocortin protects coronary endothelial function during ischemia-reperfusion: A brief communication
- Source :
- ResearcherID
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Abstract
- Urocortin is a vasodilator peptide related to corticotrophin-releasing factor, which may protect myocardium during coronary ischemia-reperfusion. To study whether urocortin also protects coronary endothelial function during ischemia-reperfusion, hearts from Sprague-Dawley rats were perfused at constant flow and then exposed to 15 mins ischemia followed by 15 mins reperfusion. In one series of experiments, we found that the coronary relaxation to urocortin (10–11 to 10–8 M) was reduced by ischemia-reperfusion (51 ± 4% vs. 79 ± 4% of the active tone, for the 10–10 Mdose). In other series of experiments, we observed that ischemia-reperfusion reduced the coronary relaxation to a test dose of acetylcholine (10–6 M) (25 ± 2% vs. 54 ± 9% of active tone), without modifying the relaxation to sodium nitroprusside (10–6 M). Treatment with a low threshold concentration of urocortin (10–11 M), administered before ischemia and during reperfusion, partly improved the coronary relaxation to acetylcholine (36 ± 3% of active tone). These results suggest that ischemia-reperfusion impairs the coronary vasodilation to urocortin and produces endothelial dysfunction and that this endothelial dysfunction may be improved by urocortin.
- Subjects :
- Male
Nitroprusside
0301 basic medicine
medicine.medical_specialty
Cardiotonic Agents
Corticotropin-Releasing Hormone
Myocardial Ischemia
Ischemia
Myocardial Reperfusion
Vasodilation
General Biochemistry, Genetics and Molecular Biology
Rats, Sprague-Dawley
03 medical and health sciences
0302 clinical medicine
Internal medicine
medicine
Animals
Endothelial dysfunction
Urocortins
Urocortin
Relaxation (psychology)
Constant flow
business.industry
medicine.disease
Coronary Vessels
Acetylcholine
Rats
030104 developmental biology
Endocrinology
15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid
030220 oncology & carcinogenesis
Cardiology
Endothelium, Vascular
Sodium nitroprusside
business
medicine.drug
Subjects
Details
- Database :
- OpenAIRE
- Journal :
- ResearcherID
- Accession number :
- edsair.doi.dedup.....1cd78691b57d427473471914bf0ed268