Back to Search
Start Over
Inflammatory bowel disease: Moving toward a stem cell-based therapy
- Publication Year :
- 2008
-
Abstract
- The incidence and prevalence of Crohn's disease (CD) and ulcerative colitis (UC), the two major forms of inflammatory bowel diseases (IBD), are rising in western countries. The modern hygienic lifestyle is probably at the root of a disease where, in genetically susceptible hosts, the intestinal commensal flora triggers dysregulated immune and inflammatory responses. Current therapies ranging from anti-inflammatory drugs to immunosuppressive regimens, remain inadequate. Advances in our understanding of the cell populations involved in the pathogenetic processes and recent findings on the regenerative, trophic and immunoregulatory potential of stem cells open new paths in IBD therapy. Hematopoietic and mesenchymal stem cells are catalyzing the attention of IBD investigators. This review highlights the pivotal findings for stem cell-based approaches to IBD therapy and collects the encouraging results coming in from clinical trials.
- Subjects :
- business.industry
medicine.medical_treatment
Mesenchymal stem cell
Gastroenterology
Hematopoietic Stem Cell Transplantation
General Medicine
Disease
Hematopoietic stem cell transplantation
Review
medicine.disease
Inflammatory Bowel Diseases
Mesenchymal Stem Cell Transplantation
Inflammatory bowel disease
Ulcerative colitis
digestive system diseases
Haematopoiesis
Immune system
Immunology
medicine
Humans
Stem cell
business
Stem Cell Transplantation
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Accession number :
- edsair.doi.dedup.....1cffe75d591c59f659f4ec1a9d827bca