Back to Search
Start Over
In vivo biodistribution and synergistic toxicity of silica nanoparticles and cadmium chloride in mice
- Source :
- Journal of Hazardous Materials. 260:780-788
- Publication Year :
- 2013
- Publisher :
- Elsevier BV, 2013.
-
Abstract
- Silica nanoparticles (SiNPs) are now in daily use due to their low intrinsic toxicity. Cadmium is a ubiquitous environmental pollutant. In spite of real risk of humans' co-exposure to SiNPs and cadmium, their synergistic toxicity is still unclear. Here, we report the synergistic effects of SiNPs and CdCl₂ on their biodistribution and subacute toxicity in mice. The biodistributions, histopathological changes, serum biochemical parameters and oxidative stress responses were determined after intraperitoneal injection of SiNPs and/or CdCl₂ to mice. SiNPs and CdCl₂ have a positive synergistic toxicity in mice. Although SiNPs were low toxic to mice, co-exposure of SiNPs and CdCl₂ significantly enhanced CdCl₂-induced oxidative damage in the liver as indicated by the severe liver dysfunction and histopathological abnormalities. Co-exposure to SiNPs and CdCl₂ markedly increased the cadmium accumulation in the liver, which induced significant hepatic oxidative stress. In vitro binding assays indicated that serum albumin and Cd(2+) mutually enhanced the binding of each other to SiNPs via the interaction of serum albumin and Cd(2+). The uptake of serum albumin- and Cd(2+)-bound SiNPs by the macrophages significantly increased cadmium accumulation in mice. These results demonstrate that serum albumins play an important role in the positive synergistic toxicity of SiNPs and CdCl₂.
- Subjects :
- Male
Biodistribution
Environmental Engineering
Health, Toxicology and Mutagenesis
medicine.medical_treatment
Intraperitoneal injection
Serum albumin
chemistry.chemical_element
Pharmacology
Cadmium chloride
Kidney
medicine.disease_cause
Mice
chemistry.chemical_compound
Cadmium Chloride
Microscopy, Electron, Transmission
In vivo
medicine
Animals
Nanotechnology
Environmental Chemistry
Tissue Distribution
Particle Size
Waste Management and Disposal
Serum Albumin
Cadmium
biology
Chemistry
Liver Diseases
Drug Synergism
Silicon Dioxide
Pollution
Oxidative Stress
Liver
Biochemistry
Toxicity
biology.protein
Nanoparticles
Biomarkers
Oxidative stress
Protein Binding
Subjects
Details
- ISSN :
- 03043894
- Volume :
- 260
- Database :
- OpenAIRE
- Journal :
- Journal of Hazardous Materials
- Accession number :
- edsair.doi.dedup.....1d00b6e152ca524bc9621980ab1dab9a