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Role of the microtubule-associated TPPP/p25 in Parkinson’s and related diseases and its therapeutic potential
- Source :
- Expert Review of Proteomics, Expert Review of Proteomics, Taylor & Francis, 2017, 14 (4), pp.301-309. ⟨10.1080/14789450.2017.1304216⟩, Expert Review of Proteomics, 2017, 14 (4), pp.301-309. ⟨10.1080/14789450.2017.1304216⟩
- Publication Year :
- 2017
- Publisher :
- Informa UK Limited, 2017.
-
Abstract
- The discovery and development of therapeutic strategies for the treatments of Parkinson's disease (PD) and other synucleinopathies are limited by a lack of understanding of the pathomechanisms and their connection with different diseases such as cancers. Areas covered: The hallmarks of these diseases are frequently multifunctional disordered proteins displaying moonlighting and/or chameleon features, which are challenging drug targets. A representative of these proteins is the disordered Tubulin Polymerization Promoting Protein (TPPP/p25) expressed specifically in oligodendrocytes (OLGs) in normal brain. Its non-physiological level is tightly related to the etiology of PD and Multiple System Atrophy (TPPP/p25 enrichment in inclusions of neurons and OLGs, respectively), multiple sclerosis (TPPP/p25-positive OLG destruction), as well as glioma (loss of TPPP/p25 expression). The established anti-proliferative potency of TPPP/p25 may raise its influence in cancer development. The recognition that whereas too much TPPP/p25 could kill neurons in PD, but its loss keeps cells alive in cancer could contribute to our understanding of the interrelationship of 'TPPP/p25 diseases'. Expert commentary: The knowledge accumulated so far underlines the key roles of the multifunctional TPPP/p25 in both physiological and diverse pathological processes, consequently its validation as drug target sorely needs a new innovative strategy that is briefly reviewed here.
- Subjects :
- 0301 basic medicine
Multiple Sclerosis
Drug target
Nerve Tissue Proteins
Disease
Biology
Biochemistry
03 medical and health sciences
0302 clinical medicine
Microtubule
medicine
Humans
Molecular Biology
ComputingMilieux_MISCELLANEOUS
Cell Proliferation
Neurons
Regulation of gene expression
Synucleinopathies
Multiple sclerosis
Brain
Cancer
Parkinson Disease
Glioma
[CHIM.CATA]Chemical Sciences/Catalysis
Multiple System Atrophy
medicine.disease
female genital diseases and pregnancy complications
eye diseases
3. Good health
Oligodendroglia
030104 developmental biology
Gene Expression Regulation
Cancer development
Neuroscience
030217 neurology & neurosurgery
Subjects
Details
- ISSN :
- 17448387 and 14789450
- Volume :
- 14
- Database :
- OpenAIRE
- Journal :
- Expert Review of Proteomics
- Accession number :
- edsair.doi.dedup.....1d09280479c5c518457f904935e56523
- Full Text :
- https://doi.org/10.1080/14789450.2017.1304216