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Sesquiterpenoids from Artemisia argyi and their NO production inhibitory activity in RAW264.7 cells

Sesquiterpenoids from Artemisia argyi and their NO production inhibitory activity in RAW264.7 cells

Authors :
Gui-Min Xue
Han-Wei Li
Chen-Guang Zhao
Yan-Jun Sun
Jin-Feng Xue
Wei-Sheng Feng
Kun Du
Zhen-Zhu Zhao
Publication Year :
2019
Publisher :
Taylor & Francis, 2019.

Abstract

Investigation into the chemical diversity of Artemisia argyi led to the discovery of two new (1, 4) and four known (2-3, 5-6) sesquiterpenoids. The new structures were determined via extensive spectroscopic data, including IR, UV, MS, and NMR, and the absolute configurations of these compounds were elucidated by calculated ECD method. All isolates were tested for their inhibitory activity against NO production in RAW 264.7 macrophages, and the isolated sesquiterpenoids exhibited NO production inhibitory activity with IC50 values ranging from 1.91 to 36.52 μM.

Details

Database :
OpenAIRE
Accession number :
edsair.doi.dedup.....1d0f37d9f11d09f3933eaa8b38a53aa7
Full Text :
https://doi.org/10.6084/m9.figshare.10120799.v1