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Differential Association of Serum BDNF With Poststroke Depression and Poststroke Anxiety
- Source :
- Archives of Physical Medicine and Rehabilitation. 101:1355-1366
- Publication Year :
- 2020
- Publisher :
- Elsevier BV, 2020.
-
Abstract
- Objectives To investigate the correlation between brain-derived neurotrophic factor (BDNF) and risk factors, as well as functional outcome in poststroke depression (PSD) or poststroke anxiety (PSA). Design Cohort study. Setting Stroke patients admitted to an urban rehabilitation hospital. Participants Stroke patients (N=162) without any previous history of depression and anxiety. Interventions Not applicable. Main Outcome Measures Sociodemographic information and comorbidities were recorded during hospital admission. Functional outcomes were assessed using FIM scores at time of admission and discharge. The influence of various factors such as BDNF and patient characteristics on functional outcome was investigated. Single-factor effect was examined using simple logistic regression, as was multi-factor effect using multiple logistic regression. The goodness-of-fit of those regression models was evaluated by the integrated area under ROC curve. Results PSD was diagnosed in 61 (37.7%) patients, and PSA was diagnosed in 40 (24.7%). Multiple logistic analysis showed that BDNF, divorce or separation, and history of smoking were significantly associated with the occurrence of PSD but not with the occurrence of PSA. The model combining low BDNF level and divorce or separation improved the prediction for PSD. Among the variables analyzed for prediction of functional outcome, serum BDNF had a minimum correlation with motor FIM scores in PSD but no significant correlation with motor FIM scores in PSA. Conclusions BDNF is a valuable prediction for the occurrence of PSD but not for PSA. More strikingly, ischemic stroke patients who are divorced or separated with low serum BDNF have a much higher risk for PSD. BDNF has a minimum correlation with motor function outcome in PSD but no significant correlation with motor outcome in PSA.
- Subjects :
- Male
030506 rehabilitation
medicine.medical_specialty
Separation (statistics)
Physical Therapy, Sports Therapy and Rehabilitation
Anxiety
Logistic regression
Cohort Studies
03 medical and health sciences
0302 clinical medicine
Divorce
Risk Factors
Internal medicine
medicine
History of depression
Humans
Stroke
Aged
Aged, 80 and over
Depression
business.industry
Brain-Derived Neurotrophic Factor
Rehabilitation
Stroke Rehabilitation
Odds ratio
Middle Aged
Physical Functional Performance
medicine.disease
Confidence interval
Treatment Outcome
nervous system
Female
medicine.symptom
0305 other medical science
business
030217 neurology & neurosurgery
Cohort study
Subjects
Details
- ISSN :
- 00039993
- Volume :
- 101
- Database :
- OpenAIRE
- Journal :
- Archives of Physical Medicine and Rehabilitation
- Accession number :
- edsair.doi.dedup.....1d175d909c3f0cea5f7f66e32de2f259