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Effect of cytomegalovirus-induced immune response, self antigen-induced immune response, and microbial translocation on chronic immune activation in successfully treated HIV type 1-infected patients: the ANRS CO3 Aquitaine Cohort
- Source :
- The Internet Journal of Infectious Diseases, The Internet Journal of Infectious Diseases, Internet Scientific Publications, LLC, 2013, 207, pp.622-7, Journal of Infectious Diseases, Journal of Infectious Diseases, 2013, 207 (4), pp.622-7. ⟨10.1093/infdis/jis732⟩, The Internet Journal of Infectious Diseases, 2013, 207, pp.622-7
- Publication Year :
- 2013
- Publisher :
- HAL CCSD, 2013.
-
Abstract
- International audience; We evaluated the impact of cytomegalovirus (CMV)-induced immune responses, autoimmune-induced immune responses, and microbial translocation on immune activation in 191 human immunodeficiency virus type 1-infected patients from the ANRS CO3 Aquitaine Cohort. All enrolled subjects had achieved long-term virological suppression during receipt of combination antiretroviral therapy (cART). HLA-DR(+)/CD38(+) expression was 16.8% among CD8(+) T cells. Independent of age, CD4(+) T-cell count, 16S ribosomal DNA load, and regulatory T-cell count, positive results of Quantiferon CMV analysis (P = .02), positive results of CMV-pp65 enzyme-linked immunosorbent spot analysis (P = .01), positive results of CMV-pp65-specific CD8(+) T-cell analysis (P = .05), and CMV seropositivity (P = .01) were associated with a higher percentage of CD8+ T cells that expressed HLA-DR+/CD38+. Autoimmune response and microbial translocation were not associated with immune activation. Therefore, the CMV-induced immune response seems to be associated with chronic immune activation in cART recipients with sustained virological suppression.
- Subjects :
- Male
Cytomegalovirus
Autoimmunity
HIV Infections
CD8-Positive T-Lymphocytes
CD38
Lymphocyte Activation
medicine.disease_cause
Cohort Studies
0302 clinical medicine
[SDV.MHEP.MI]Life Sciences [q-bio]/Human health and pathology/Infectious diseases
[ SDV.MP ] Life Sciences [q-bio]/Microbiology and Parasitology
Antiretroviral Therapy, Highly Active
Immunology and Allergy
030212 general & internal medicine
MESH: Cytomegalovirus Infections/immunology
MESH: HLA-DR Antigens/metabolism
MESH: Cohort Studies
0303 health sciences
MESH: HIV Infections/drug therapy
virus diseases
Viral Load
3. Good health
Infectious Diseases
[SDV.MP]Life Sciences [q-bio]/Microbiology and Parasitology
MESH: CD8-Positive T-Lymphocytes/immunology
Cytomegalovirus Infections
[SDV.MHEP.MI] Life Sciences [q-bio]/Human health and pathology/Infectious diseases
[SDV.IMM]Life Sciences [q-bio]/Immunology
Female
France
MESH: Cytomegalovirus/immunology
MESH: Viral Load
[SDV.IMM] Life Sciences [q-bio]/Immunology
Congenital cytomegalovirus infection
Human leukocyte antigen
Biology
QuantiFERON
Viral Matrix Proteins
03 medical and health sciences
Immune system
MESH: Cross-Sectional Studies
Antigen
MESH: Autoimmunity
medicine
Humans
MESH: Phosphoproteins/immunology
[SDV.MP] Life Sciences [q-bio]/Microbiology and Parasitology
MESH: Viral Matrix Proteins/immunology
030304 developmental biology
MESH: Humans
MESH: HIV-1/genetics
MESH: HIV-1/physiology
MESH: HIV Infections/immunology
HLA-DR Antigens
Phosphoproteins
medicine.disease
Virology
MESH: Male
MESH: Lymphocyte Activation/immunology
MESH: France
Cross-Sectional Studies
[SDV.SPEE] Life Sciences [q-bio]/Santé publique et épidémiologie
Immunology
HIV-1
[SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie
MESH: HIV-1/drug effects
MESH: Female
CD8
Subjects
Details
- Language :
- English
- ISSN :
- 15288366, 00221899, and 15376613
- Database :
- OpenAIRE
- Journal :
- The Internet Journal of Infectious Diseases, The Internet Journal of Infectious Diseases, Internet Scientific Publications, LLC, 2013, 207, pp.622-7, Journal of Infectious Diseases, Journal of Infectious Diseases, 2013, 207 (4), pp.622-7. ⟨10.1093/infdis/jis732⟩, The Internet Journal of Infectious Diseases, 2013, 207, pp.622-7
- Accession number :
- edsair.doi.dedup.....1d1ca0d58a4e522c9a8ba04b7584b6b8