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TORC1 and TORC2 Coactivators Are Required for Tax Activation of the Human T-Cell Leukemia Virus Type 1 Long Terminal Repeats
- Source :
- Journal of Virology. 80:7052-7059
- Publication Year :
- 2006
- Publisher :
- American Society for Microbiology, 2006.
-
Abstract
- Human T-cell leukemia virus type 1 (HTLV-1) Tax protein activates viral transcription from the long terminal repeats (LTR). Mechanisms through which Tax activates LTR have been established, but coactivators of this process remain to be identified and characterized. Here we show that all three members of the TORC family of transcriptional regulators are coactivators of Tax for LTR-driven expression. TORC coactivation requires CREB, but not ATF4 or other bZIP factors. Tax physically interacts with TORC1, TORC2, and TORC3 (TORC1/2/3), and the depletion of TORC1/2/3 inhibited Tax activity. TORC coactivation can be further enhanced by transcriptional coactivator p300. In addition, coactivators in the p300 family are required for full activity of Tax independently of TORC1/2/3. Thus, both TORC and p300 families of coactivators are essential for optimal activation of HTLV-1 transcription by Tax.
- Subjects :
- Gene Expression Regulation, Viral
Transcription, Genetic
Torc
viruses
Immunology
P300-CBP Transcription Factors
Activating Transcription Factor 4
CREB
Microbiology
Transcription (biology)
Virology
Humans
p300-CBP Transcription Factors
Cyclic AMP Response Element-Binding Protein
Transcription factor
health care economics and organizations
Genetics
Human T-lymphotropic virus 1
biology
Terminal Repeat Sequences
Gene Products, tax
Phosphoproteins
Coactivation
Long terminal repeat
Genome Replication and Regulation of Viral Gene Expression
Insect Science
Trans-Activators
biology.protein
Virus Activation
HeLa Cells
Protein Binding
Transcription Factors
Subjects
Details
- ISSN :
- 10985514 and 0022538X
- Volume :
- 80
- Database :
- OpenAIRE
- Journal :
- Journal of Virology
- Accession number :
- edsair.doi.dedup.....1d2c70e08d5547467cb0cff4bb2b2676