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Monoclonal antibodies to epithelium-specific components of the human milk fat globule membrane: production and reaction with cells in culture
- Source :
- International journal of cancer. 28(1)
- Publication Year :
- 1981
-
Abstract
- Three hybridomas producing monoclonal antibodies (IgG), reacting with components of the human mammary milk fat globule have been isolated. When tested for binding to a wide range of human cell lines and strains, all three antibodies show negative reactions with fibroblasts, lymphoblastoid cells, and a large number of epithelial cell lines of non-breast origin. Two of the antibodies (1.10.F3 and 3.14.A3) reacted with seven out of eight breast cancer lines tested, and with epithelial cells cultured from human milk. The other antibody (3.15.C3) reacted with only two of the breast cancer cell lines.
- Subjects :
- Cancer Research
medicine.drug_class
Breast Neoplasms
Monoclonal antibody
Epithelium
Cell Line
Fats
Mice
Breast cancer
Breast cancer cell line
medicine
Animals
Humans
Breast
Milk fat globule
Mice, Inbred BALB C
Hybridomas
biology
Milk, Human
Chemistry
Lymphoblast
Antibodies, Monoclonal
medicine.disease
Molecular biology
Membrane
medicine.anatomical_structure
Oncology
biology.protein
Female
Antibody
Subjects
Details
- ISSN :
- 00207136
- Volume :
- 28
- Issue :
- 1
- Database :
- OpenAIRE
- Journal :
- International journal of cancer
- Accession number :
- edsair.doi.dedup.....1d311ff8f7d7e6b7e976790e5fe76a78