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Isoflurane does not aggregate inside POPC bilayers at high pressure: Implications for pressure reversal of general anaesthesia
- Source :
- Chemical Physics Letters, Chemical Physics Letters, 2015, 638, pp.116-121. ⟨10.1016/j.cplett.2015.07.065⟩, Chemical Physics Letters, Elsevier, 2015, 638, pp.116-121. ⟨10.1016/j.cplett.2015.07.065⟩
- Publisher :
- The Authors. Published by Elsevier B.V.
-
Abstract
- International audience; We placed isoflurane, a general anaesthetic, inside palmitoyloleoylphosphatidylcholine (POPC) bilay-ers at clinical concentration, and performed molecular dynamics simulations at atmospheric and raised pressures, using two different thermodynamic ensembles. We also performed a simulation of this system with isoflurane at ten times the clinical concentration. We found that isoflurane did not aggregate inside POPC membranes at 20 MPa, nor at 40 MPa. The implications of these findings for pressure reversal is discussed, in light of the high-pressure neurological syndrome.
- Subjects :
- Aggregate (composite)
Isoflurane
General Physics and Astronomy
Physics and Astronomy(all)
POPC
[SDV.BIBS]Life Sciences [q-bio]/Quantitative Methods [q-bio.QM]
chemistry.chemical_compound
Membrane
chemistry
High pressure
Neurological syndrome
medicine
Biophysics
general anaesthesia
General anaesthesia
Physical and Theoretical Chemistry
General anaesthetic
medicine.drug
Subjects
Details
- Language :
- English
- ISSN :
- 00092614
- Database :
- OpenAIRE
- Journal :
- Chemical Physics Letters
- Accession number :
- edsair.doi.dedup.....1d3dddf206527bdd8095aa1e69559ed4
- Full Text :
- https://doi.org/10.1016/j.cplett.2015.07.065