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Dual-balloon infusion microcatheter for selective drug-eluting bead transarterial chemoembolization: initial feasibility study
- Source :
- Diagnostic and Interventional Radiology. 23:454-460
- Publication Year :
- 2017
- Publisher :
- Galenos Yayinevi, 2017.
-
Abstract
- PURPOSE We aimed to demonstrate feasibility of the use of a dual-balloon infusion microcatheter for segmental/subsegmental drug-eluting bead transarterial chemoembolization (DEB-TACE). METHODS Over a 16-month period, 15 segmental and 21 subsegmental DEB-TACE procedures were attempted using a dual-balloon anti-reflux microcatheter (IsoFlow™ microcatheter, Vascular Designs Inc.) in 21 patients (15 males; median age, 61 years; range, 49-82 years) with hepatocellular carcinoma (Barcelona clinic liver cancer stage A [n=4]; B [n=12]; C [n=5]) with one to three tumors, median size of 3.4 cm (1.2-9 cm). Follow-up enhanced computed tomography or magnetic resonance imaging was obtained at one month then subsequently every three months for one year. Technical success was evaluated. Modified RECIST criteria was used for target tumor response assessment. Safety was evaluated by assessing for arterial injury and hepatic injury at the time of the procedure and subsequent evidence of complications and liver toxicity. RESULTS In 26 of the procedures, the segmental/subsegmental arteries were thought not to be easily selected with standard microcatheters due to the arterial branches being severely tortuous/angulated or atretic from prior TACE or anti-angiogenic therapy or could not be catheterized. Radiologic response assessment of treated tumors demonstrated 32% complete response, 19% partial response, 34% stable disease, and 15% progressive disease. No complications occurred. The median time to progression for the targeted tumors was 7 months (range, 3-12 months). CONCLUSION DEB-TACE, using this dual-balloon anti-reflux infusion microcatheter is feasible and safe.
- Subjects :
- Male
Carcinoma, Hepatocellular
Catheters
Every Three Months
Balloon
Tumor response
030218 nuclear medicine & medical imaging
03 medical and health sciences
0302 clinical medicine
Text mining
Interventional Radiology
medicine
Humans
Radiology, Nuclear Medicine and imaging
Chemoembolization, Therapeutic
Aged
Retrospective Studies
Aged, 80 and over
Drug eluting beads
medicine.diagnostic_test
business.industry
Liver Neoplasms
Magnetic resonance imaging
Equipment Design
Middle Aged
medicine.disease
Magnetic Resonance Imaging
Treatment Outcome
Hepatocellular carcinoma
Feasibility Studies
Female
030211 gastroenterology & hepatology
Tomography, X-Ray Computed
Cardiology and Cardiovascular Medicine
business
Nuclear medicine
Progressive disease
Subjects
Details
- ISSN :
- 13053612 and 13053825
- Volume :
- 23
- Database :
- OpenAIRE
- Journal :
- Diagnostic and Interventional Radiology
- Accession number :
- edsair.doi.dedup.....1d4c8dc84d2e465a11e1bac3cf092ff9