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Renal cell carcinoma of native kidney in Chinese renal transplant recipients: a report of 12 cases and a review of the literature
- Source :
- International Urology and Nephrology
- Publication Year :
- 2011
- Publisher :
- Springer Science and Business Media LLC, 2011.
-
Abstract
- Objectives To present and discuss the epidemiological and clinical aspects, as well as therapeutic options and outcome of de novo renal cell carcinoma (RCC) of the native kidneys in a series of Chinese renal transplant recipients. Patients and Methods A retrospective, cohort study examining all renal transplant recipients with the diagnosis of RCC of native kidney followed up in two major regional hospitals in Hong Kong between January 2000 and December 2009. Clinical data includedage, gender, cause of renal failure, symptoms at presentation, duration of transplantation, immunosuppressive therapy, and history of acquired cystic kidney disease (ACKD). Laboratory, radiographic, operative, and pathology reports were used to assess the tumor extent. Results Among the 1,003 renal transplant recipients recruited, 12 transplant recipients had a nephrectomy for a total of 13 RCC. The prevalence of de novo RCC was 1.3%. The mean age at diagnosis of RCC was 48.4 years, and the median time from transplantation to diagnosis was 6.1 years. ACKD was found in 6 (50%) of the patients. All patients except one were asymptomatic. pT1 disease was found in ten patients with a mean tumor size of 3.2 cm. All patients were treated successfully with radical nephrectomy. After a median follow-up of 38 months, two patients (16.7%) died. One died of sepsis, and the other died of metastatic carcinoma. Conclusions With increasing data showing a better prognosis if RCC is detected early by screening, it is time to consider screening all kidney transplant recipients for ACKD and RCC. © The Author(s) 2011. This article is published with open access at Springerlink.com.<br />published_or_final_version<br />Springer Open Choice, 21 Feb 2012
- Subjects :
- Adult
Male
Nephrology
medicine.medical_specialty
Urology
medicine.medical_treatment
urologic and male genital diseases
Nephrectomy
Renal cell carcinoma
Internal medicine
Acquired cystic kidney disease
Ultrasound
Epidemiology
Prevalence
medicine
Carcinoma
Humans
Carcinoma, Renal Cell
Kidney transplantation
Aged
Retrospective Studies
Immunosuppression Therapy
Chinese
business.industry
Immunosuppression
Retrospective cohort study
Kidney Diseases, Cystic
Middle Aged
medicine.disease
Kidney Transplantation
Kidney Neoplasms
Urology – Original Paper
Hong Kong
Female
business
Subjects
Details
- ISSN :
- 15732584 and 03011623
- Volume :
- 43
- Database :
- OpenAIRE
- Journal :
- International Urology and Nephrology
- Accession number :
- edsair.doi.dedup.....1d71543b404aa6d2d1eaa77f47b68425