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Fast ripple analysis in human mesial temporal lobe epilepsy suggests two different seizure-generating mechanisms
- Source :
- Neurobiology of Disease, Vol 127, Iss, Pp 374-381 (2019)
- Publication Year :
- 2019
- Publisher :
- Elsevier, 2019.
-
Abstract
- Objective: The distinction of hypersynchronous (HYP) and low-voltage fast (LVF) onset seizures in mesial temporal lobe epilepsy (MTLE) is well established, but classifying individual seizures and patients is often challenging. Experimental work indicates a strong association of HYP with fast ripples (250–500 Hz) and of LVF with ripples (80–250 Hz). We aimed to investigate whether analysis of high-frequency oscillations can be useful for characterizing the process of seizure generation in human MTLE patients. Methods: We retrospectively compared 19 HYP and 14 LVF onset clinical seizures from ten and six consecutive MTLE patients with a predominance of the respective pattern. Five-second intervals of stereotactic EEGs from the seizure onset zone were selected, each representing the onset of HYP and LVF, the corresponding pre-ictal periods and, after the large spikes of HYP onsets, the LVF-like pattern that frequently followed. Results: Pre-ictal fast ripple density and rate were higher for HYP than for LVF seizures (p .05). Fast ripple (p
- Subjects :
- Adult
Male
0301 basic medicine
medicine.medical_specialty
Ripple
Seizure onset zone
Audiology
lcsh:RC321-571
Young Adult
03 medical and health sciences
Epilepsy
0302 clinical medicine
Seizures
Seizure onset pattern
medicine
Humans
Experimental work
lcsh:Neurosciences. Biological psychiatry. Neuropsychiatry
High-frequency oscillations
Retrospective Studies
business.industry
Brain
Electroencephalography
Mesial temporal lobe epilepsy
Middle Aged
medicine.disease
Brain Waves
Fast ripples
030104 developmental biology
Epilepsy, Temporal Lobe
Neurology
Seizure classification
Female
business
030217 neurology & neurosurgery
Subjects
Details
- Language :
- English
- Volume :
- 127
- Database :
- OpenAIRE
- Journal :
- Neurobiology of Disease
- Accession number :
- edsair.doi.dedup.....1d807757f840da754aa3077f73f17185