Back to Search
Start Over
CD10+ Cells and IgM in Pathogen Response in Lumpfish (Cyclopterus lumpus) Eye Tissues
- Source :
- Frontiers in Immunology, Frontiers in Immunology, Vol 11 (2020)
- Publication Year :
- 2020
- Publisher :
- Frontiers Media S.A., 2020.
-
Abstract
- Lumpfish (Cyclopterus lumpus), a North Atlantic “cleaner“ fish, is utilized to biocontrol salmon louse (Lepeophtheirus salmonis) in Atlantic salmon (Salmo salar) farms. Lumpfish require excellent vision to scan for and eat louse on salmon skin. The lumpfish eye immune response to infectious diseases has not been explored. We examined the ocular response to a natural parasite infection in wild lumpfish and to an experimental bacterial infection in cultured lumpfish. Cysts associated with natural myxozoan infection in the ocular scleral cartilage of wild adult lumpfish harbored cells expressing cluster of differentiation 10 (CD10) and immunoglobulin M (IgM). Experimental Vibrio anguillarum infection, which led to exophthalmos and disorganization of the retinal tissues was associated with disruption of normal CD10 expression, CD10+ cellular infiltration and IgM expression. We further describe the lumpfish CD10 orthologue and characterize the lumpfish scleral skeleton in the context of myxozoan scleral cysts. We propose that lumpfish develop an intraocular response to pathogens, exemplified herein by myxozoan and V. anguillarum infection involving novel CD10+ cells and IgM+ cells to contain and mitigate damage to eye structures. This work is the first demonstration of CD10 and IgM expressing cells in a novel ocular immune system component in response to disease in a teleost.
- Subjects :
- lcsh:Immunologic diseases. Allergy
0301 basic medicine
Fish Proteins
Vibrio anguillarum
genetic structures
Cyclopterus lumpus
animal diseases
Parasitic Diseases, Animal
Immunology
Context (language use)
Eye
immune response
Microbiology
03 medical and health sciences
Immune system
Salmon louse
Immunology and Allergy
Animals
Exophthalmos
Myxozoa
Original Research
Vibrio
biology
Cysts
Ocular immune system
Fishes
04 agricultural and veterinary sciences
biology.organism_classification
eye diseases
infection
030104 developmental biology
Gene Expression Regulation
Immunoglobulin M
Lepeophtheirus
Vibrio Infections
040102 fisheries
biology.protein
0401 agriculture, forestry, and fisheries
Neprilysin
sense organs
cluster of differentiation 10
lumpfish (Cyclopterus lumpus L.)
lcsh:RC581-607
Subjects
Details
- Language :
- English
- ISSN :
- 16643224
- Volume :
- 11
- Database :
- OpenAIRE
- Journal :
- Frontiers in Immunology
- Accession number :
- edsair.doi.dedup.....1d93facdb4ab15aaed103890f6bc2fe3