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Apathy in patients with Parkinson's disease following deep brain stimulation of the subthalamic nucleus
- Source :
- CNS spectrums. 21(3)
- Publication Year :
- 2016
-
Abstract
- ObjectiveApathy has been reported as a possible adverse effect of deep brain stimulation of the subthalamic nucleus (STN-DBS). We investigated the prevalence and severity of apathy in 22 patients with Parkinson’s disease (PD) who underwent STN-DBS, as well as the effects of apathy on quality of life (QOL).MethodsAll patients were assessed with the Lille Apathy Rating Scale (LARS), the Apathy Scale (AS), and the Parkinson’s Disease Questionnaire and were compared to a control group of 38 patients on pharmacotherapy alone.ResultsThere were no significant differences in the prevalence or severity of apathy between patients who had undergone STN-DBS and those on pharmacotherapy alone. Significant correlations were observed between poorer QOL and degree of apathy, as measured by the LARS (pConclusionOur findings suggest that STN-DBS is not necessarily associated with apathy in the PD population; however, more severe apathy appears to be associated with a higher level of disability due to PD and worse QOL, but no other clinico-demographic characteristics.
- Subjects :
- Male
medicine.medical_specialty
Deep brain stimulation
Parkinson's disease
medicine.medical_treatment
Deep Brain Stimulation
Population
Apathy
Severity of Illness Index
050105 experimental psychology
Antiparkinson Agents
03 medical and health sciences
0302 clinical medicine
Pharmacotherapy
Quality of life
Risk Factors
Subthalamic Nucleus
Internal medicine
Severity of illness
medicine
Prevalence
Humans
0501 psychology and cognitive sciences
education
Aged
education.field_of_study
behavior
05 social sciences
Parkinson Disease
Middle Aged
medicine.disease
Psychiatry and Mental health
Subthalamic nucleus
Case-Control Studies
Physical therapy
Quality of Life
Female
Neurology (clinical)
medicine.symptom
Psychology
030217 neurology & neurosurgery
Subjects
Details
- ISSN :
- 10928529
- Volume :
- 21
- Issue :
- 3
- Database :
- OpenAIRE
- Journal :
- CNS spectrums
- Accession number :
- edsair.doi.dedup.....1d957d3c972b5165f65a8918c297e9d8