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Striatal D2/D3 receptor occupancy, clinical response and side effects with amisulpride: an iodine-123-iodobenzamide SPET study

Authors :
H.-J. Möller
R. Boerner
Johanna Scheuerecker
G. J. E. Schmitt
E. M. Meisenzahl
Thomas Frodl
Gerhard Gründer
Stefan Dresel
C. la Fougère
Jan Stauss
Klaus Hahn
Markus J. Schwarz
Source :
Pharmacopsychiatry. 41(5)
Publication Year :
2008

Abstract

INTRODUCTION: Amisulpride appears to be an effective atypical agent for treating schizophrenia in a dose-dependent manner. METHODS: 29 patients suffering from schizophrenia or schizoaffective disorder were treated with a broad dose range of amisulpride (50-1 200 mg/day, mean: 455.2±278.8 mg/day). After 2 weeks, brain single photon emission tomography (SPET) scans were performed two hours after intravenous injection of 185 MBq [ 123 I]IBZM. Clinical evaluations and ratings of extrapyramidal symptoms were performed at baseline and after steady state treatment of two weeks with amisulpride. RESULTS: In patients treated with amisulpride, specific binding of [ 123 I]IBZM to D2 receptors was significantly decreased (p

Details

ISSN :
01763679
Volume :
41
Issue :
5
Database :
OpenAIRE
Journal :
Pharmacopsychiatry
Accession number :
edsair.doi.dedup.....1d9a2f3eac3ca77f8869f9d2a7a5b92e