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Striatal D2/D3 receptor occupancy, clinical response and side effects with amisulpride: an iodine-123-iodobenzamide SPET study
- Source :
- Pharmacopsychiatry. 41(5)
- Publication Year :
- 2008
-
Abstract
- INTRODUCTION: Amisulpride appears to be an effective atypical agent for treating schizophrenia in a dose-dependent manner. METHODS: 29 patients suffering from schizophrenia or schizoaffective disorder were treated with a broad dose range of amisulpride (50-1 200 mg/day, mean: 455.2±278.8 mg/day). After 2 weeks, brain single photon emission tomography (SPET) scans were performed two hours after intravenous injection of 185 MBq [ 123 I]IBZM. Clinical evaluations and ratings of extrapyramidal symptoms were performed at baseline and after steady state treatment of two weeks with amisulpride. RESULTS: In patients treated with amisulpride, specific binding of [ 123 I]IBZM to D2 receptors was significantly decreased (p
- Subjects :
- Adult
Male
Pyrrolidines
medicine.drug_class
Atypical antipsychotic
Pharmacology
Severity of Illness Index
Statistics, Nonparametric
Iodine Radioisotopes
chemistry.chemical_compound
Iodobenzamide
Extrapyramidal symptoms
Dopamine receptor D2
medicine
Humans
Pharmacology (medical)
Amisulpride
Tomography, Emission-Computed, Single-Photon
Dose-Response Relationship, Drug
business.industry
Receptors, Dopamine D2
General Medicine
medicine.disease
Biperiden
Corpus Striatum
Psychiatry and Mental health
Tolerability
chemistry
Psychotic Disorders
Schizophrenia
Benzamides
Female
medicine.symptom
Sulpiride
business
medicine.drug
Antipsychotic Agents
Subjects
Details
- ISSN :
- 01763679
- Volume :
- 41
- Issue :
- 5
- Database :
- OpenAIRE
- Journal :
- Pharmacopsychiatry
- Accession number :
- edsair.doi.dedup.....1d9a2f3eac3ca77f8869f9d2a7a5b92e