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Biomarker discovery for drug-induced phospholipidosis: phenylacetylglycine to hippuric acid ratio in urine and plasma as potential markers
- Source :
- Biomarkers. 22:178-188
- Publication Year :
- 2016
- Publisher :
- Informa UK Limited, 2016.
-
Abstract
- Context: Drug-induced phospholipidosis is one of the significant concerns in drug development, especially in safety assessment and noninvasive diagnostic tool is highly desirable.Objective: The objective of this study is to explored novel biomarkers for phospholipidosis using a metabolomic approach.Method: NMR spectrometry and LC/MS/MS analyses were applied to urine and plasma of rats administrated cationic amphiphilic drugs.Results: The phenylacetylglycine to hippuric acid ratio in plasma was increased in time and dose-dependent manners; and it was well correlated with histopathological observation.Conclusion: The plasma phenylacetylglycine to hippuric acid ratio is a potential marker in monitoring drug-induced phospholipidosis.
- Subjects :
- 0301 basic medicine
Health, Toxicology and Mutagenesis
Clinical Biochemistry
Glycine
Urine
Pharmacology
Lipidoses
Biochemistry
03 medical and health sciences
chemistry.chemical_compound
0302 clinical medicine
Metabolomics
Animals
Biomarker discovery
Drug induced phospholipidosis
Phospholipids
Phospholipidosis
Hippurates
Hippuric acid
Rats
030104 developmental biology
chemistry
Drug development
030220 oncology & carcinogenesis
Drug Monitoring
Phenylalanine metabolism
Biomarkers
Subjects
Details
- ISSN :
- 13665804 and 1354750X
- Volume :
- 22
- Database :
- OpenAIRE
- Journal :
- Biomarkers
- Accession number :
- edsair.doi.dedup.....1dac2a5921928eebe2a0ac22705c503b