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The effect of hypertension on aortic pulse wave velocity in type-1 diabetes mellitus patients: assessment with MRI
- Source :
- International Journal of Cardiovascular Imaging, 28(3), 543-550, International Journal of Cardiovascular Imaging, 28, 3, pp. 543-50, The International Journal of Cardiovascular Imaging, International Journal of Cardiovascular Imaging, 28, 543-50
- Publisher :
- Springer Nature
-
Abstract
- Item does not contain fulltext To investigate in type-1 diabetes mellitus (DM1) patients the role of hypertension and of DM1 itself on aortic stiffness by using magnetic resonance imaging (MRI). Consecutive patients from the diabetes and hypertension outpatient clinic and healthy volunteers were included in our study. Subjects were divided into four groups: 32 healthy volunteers (mean age: 54.5 +/- 6.8 years), 20 DM1 patients (mean age: 48.3 +/- 5.9 years), 31 hypertensive patients (mean age: 59.9 +/- 7.2 years) and 28 patients with both DM1 and hypertension (mean age: 50.1 +/- 6.2 years). Aortic stiffness was measured by means of pulse wave velocity (PWV) using velocity-encoded MRI. Analysis of variance (ANOVA), uni- and multivariable regression models and the Bonferroni-test for multiple testing, were used for statistical analyses. Mean aortic PWV was 5.7 +/- 1.2 m/s in healthy volunteers, 5.9 +/- 1.2 m/s in DM1 patients without hypertension, 7.3 +/- 1.2 m/s in hypertensive patients and 7.3 +/- 1.3 m/s in patients with both DM1 and hypertension. Compared to healthy control subjects, aortic PWV was significantly higher in patients with hypertension (P < 0.001) and in patients with both DM1 and hypertension (P < 0.001), whereas aortic PWV was not increased in patients having DM1 alone. Furthermore, aortic PWV was significantly higher in DM1 patients with hypertension than in patients with DM1 alone (P = 0.002). These findings remained after adjustment for confounding factors. Hypertension has a predominant contributive effect on aortic stiffness in DM1 patients whereas the direct diabetic effect on aortic stiffness is small. 01 maart 2012
- Subjects :
- Male
musculoskeletal diseases
medicine.medical_specialty
congenital, hereditary, and neonatal diseases and abnormalities
Aortic Diseases
Diabetic angiopathy
Diabetes mellitus
medicine.artery
Internal medicine
medicine
Outpatient clinic
Humans
Radiology, Nuclear Medicine and imaging
Pulse wave velocity
Aorta
Type 1 diabetes
Original Paper
Cardiovascular diseases [NCEBP 14]
business.industry
Aortic pulse wave velocity
medicine.disease
Magnetic Resonance Imaging
Surgery
Diabetes Mellitus, Type 1
Radiology Nuclear Medicine and imaging
Predictive value of tests
Pulsatile Flow
Hypertension
Cardiology
cardiovascular system
Type-1 diabetes mellitus
Aortic stiffness
Female
business
Cardiology and Cardiovascular Medicine
Diabetic Angiopathies
MRI
Subjects
Details
- Language :
- English
- ISSN :
- 15695794
- Volume :
- 28
- Issue :
- 3
- Database :
- OpenAIRE
- Journal :
- The International Journal of Cardiovascular Imaging
- Accession number :
- edsair.doi.dedup.....1db74874328759dcd014ac034ec9143b
- Full Text :
- https://doi.org/10.1007/s10554-011-9841-2