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Device profile of the AltaValve system for transcatheter mitral valve replacement: overview of its safety and efficacy
- Source :
- Expert Review of Medical Devices. 17:627-636
- Publication Year :
- 2020
- Publisher :
- Informa UK Limited, 2020.
-
Abstract
- In patients with severe mitral regurgitation (MR), transcatheter mitral valve replacement (TMVR) has recently emerged as an alternative to surgery. However, compared with transcatheter aortic valve replacement, TMVR faces several technical challenges and a high screening failure rate, mainly due to a more complex mitral annulus geometry and the potential interaction with the sub-valvular apparatus and the left ventricular outflow tract (LVOT). The AltaValve system is a device intended for TMVR with unique design features that may overcome most anatomical limitations for this therapy.A summary of the current evidence regarding TMVR is presented, followed by a review of the main technical challenges. The main features, differential characteristics, and potential advantages of the AltaValve system are discussed. Finally, we describe the first-in-human procedures with AltaValve and the main details of the upcoming feasibility trial.A high number of high-risk surgical patients with MR remain undertreated. TMVR is continuously evolving, and AltaValve constitutes another step forward in this field. Its unique design avoiding annular and LVOT engagement represents a clear potential benefit, along with its recently incorporated trans-septal approach system. However, more evidence is warranted regarding its feasibility in different clinical settings and mid-term performance.
- Subjects :
- medicine.medical_specialty
Transcatheter aortic
medicine.medical_treatment
Biomedical Engineering
030204 cardiovascular system & hematology
03 medical and health sciences
0302 clinical medicine
Internal medicine
medicine
Animals
Humans
In patient
cardiovascular diseases
Heart Valve Prosthesis Implantation
Mitral regurgitation
business.industry
Mitral valve replacement
Calcinosis
General Medicine
Treatment Outcome
cardiovascular system
Cardiology
Feasibility Studies
Mitral Valve
Surgery
Tomography, X-Ray Computed
business
030217 neurology & neurosurgery
Subjects
Details
- ISSN :
- 17452422 and 17434440
- Volume :
- 17
- Database :
- OpenAIRE
- Journal :
- Expert Review of Medical Devices
- Accession number :
- edsair.doi.dedup.....1ddac0d6189590003d21186cfdf381b0
- Full Text :
- https://doi.org/10.1080/17434440.2020.1781616