Back to Search
Start Over
Plasticity of intrinsic excitability across the estrous cycle in hypothalamic CRH neurons
- Source :
- Scientific Reports, Vol 11, Iss 1, Pp 1-7 (2021), Scientific Reports
- Publication Year :
- 2021
- Publisher :
- Springer Science and Business Media LLC, 2021.
-
Abstract
- Stress responses are highly plastic and vary across physiological states. The female estrous cycle is associated with a number of physiological changes including changes in stress responses, however, the mechanisms driving these changes are poorly understood. Corticotropin-releasing hormone (CRH) neurons are the primary neural population controlling the hypothalamic–pituitary–adrenal (HPA) axis and stress-evoked corticosterone secretion. Here we show that CRH neuron intrinsic excitability is regulated over the estrous cycle with a peak in proestrus and a nadir in estrus. Fast inactivating voltage-gated potassium channel (IA) currents showed the opposite relationship, with current density being lowest in proestrus compared to other cycle stages. Blocking IA currents equalized excitability across cycle stages revealing a role for IA in mediating plasticity in stress circuit function over the female estrous cycle.
- Subjects :
- Cell biology
endocrine system
medicine.medical_specialty
Physiology
Corticotropin-Releasing Hormone
Science
Hypothalamus
Pituitary-Adrenal System
Estrous Cycle
Plasticity
Biology
Neural population
Article
Mice
chemistry.chemical_compound
Endocrinology
Stress, Physiological
Corticosterone
Internal medicine
Neuroplasticity
medicine
Animals
reproductive and urinary physiology
Neurons
Estrous cycle
Neuronal Plasticity
Multidisciplinary
urogenital system
Potassium channel
medicine.anatomical_structure
chemistry
Medicine
Female
Neuron
hormones, hormone substitutes, and hormone antagonists
Neuroscience
Hormone
Subjects
Details
- ISSN :
- 20452322
- Volume :
- 11
- Database :
- OpenAIRE
- Journal :
- Scientific Reports
- Accession number :
- edsair.doi.dedup.....1e0e6bfcfaf846f2528713d7b40b8929
- Full Text :
- https://doi.org/10.1038/s41598-021-96341-4