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Foxg1 Suppresses Early Cortical Cell Fate
- Source :
- Science. 303:56-59
- Publication Year :
- 2004
- Publisher :
- American Association for the Advancement of Science (AAAS), 2004.
-
Abstract
- During mammalian cerebral corticogenesis, progenitor cells become progressively restricted in the types of neurons they can produce. The molecular mechanism that determines earlier versus later born neuron fate is unknown. We demonstrate here that the generation of the earliest born neurons, the Cajal-Retzius cells, is suppressed by the telencephalic transcription factor Foxg1. In Foxg1 null mutants, we observed an excess of Cajal-Retzius neuron production in the cortex. By conditionally inactivating Foxg1 in cortical progenitors that normally produce deep-layer cortical neurons, we demonstrate that Foxg1 is constitutively required to suppress Cajal-Retzius cell fate. Hence, the competence to generate the earliest born neurons during later cortical development is actively suppressed but not lost.
- Subjects :
- Male
Telencephalon
Time Factors
Cell Adhesion Molecules, Neuronal
Cellular differentiation
Mice, Transgenic
Nerve Tissue Proteins
Cell fate determination
Biology
Mice
medicine
Animals
Cell Lineage
Progenitor cell
Transcription factor
Crosses, Genetic
Cerebral Cortex
Neurons
Extracellular Matrix Proteins
Multidisciplinary
Stem Cells
Serine Endopeptidases
Gene Expression Regulation, Developmental
Cell Differentiation
Forkhead Transcription Factors
Anatomy
Cell biology
DNA-Binding Proteins
Reelin Protein
Corticogenesis
FOXG1
medicine.anatomical_structure
nervous system
Cerebral cortex
Doxycycline
Mutation
Female
Neuron
Transcription Factors
Subjects
Details
- ISSN :
- 10959203 and 00368075
- Volume :
- 303
- Database :
- OpenAIRE
- Journal :
- Science
- Accession number :
- edsair.doi.dedup.....1e6150fa83bd338ed6605998b054e70c