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Animal models of bipolar disorder
- Source :
- Neuroscience & Biobehavioral Reviews. 31:832-842
- Publication Year :
- 2007
- Publisher :
- Elsevier BV, 2007.
-
Abstract
- Animal models of human diseases should meet three sets of criteria: construct validity, face validity, and predictive validity. To date, several putative animal models of bipolar disorder have been reported. They are classified into various categories: pharmacological models, nutritional models, environmental models, and genetic models. None of them, however, totally fulfills the three validity criteria, and thus may not be useful for drug development. Mounting evidence suggests that mitochondrial dysfunction has a role in bipolar disorder. To test whether accumulation of mtDNA deletions in the brain can cause bipolar disorder, we generated transgenic mice with neuron-specific expression of mutant Polg (D181A). These mice showed altered diurnal activity rhythm and periodic activity change associated with the estrous cycle. These phenotypes were worsened by administration of a tricyclic antidepressant, but improved after lithium treatment. This mouse model of bipolar disorder potentially fulfills the three validity criteria, and therefore might be used for future drug development studies.
- Subjects :
- Predictive validity
Bipolar Disorder
Mitochondrial Diseases
Psychopharmacology
medicine.drug_class
Cognitive Neuroscience
Tricyclic antidepressant
Mice, Transgenic
Mice
Behavioral Neuroscience
Cyclosporin a
Genetic model
medicine
Animals
Calcium Signaling
Bipolar disorder
Face validity
Psychotropic Drugs
Psychopathology
Construct validity
Mood stabilizer
medicine.disease
Disease Models, Animal
Neuropsychology and Physiological Psychology
Psychology
Neuroscience
Subjects
Details
- ISSN :
- 01497634
- Volume :
- 31
- Database :
- OpenAIRE
- Journal :
- Neuroscience & Biobehavioral Reviews
- Accession number :
- edsair.doi.dedup.....1e6b8792bf9083117192460ff2740528