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Osteoblast MR deficiency protects against adverse ventricular remodeling after myocardial infarction
- Source :
- Journal of Molecular and Cellular Cardiology. 167:40-51
- Publication Year :
- 2022
- Publisher :
- Elsevier BV, 2022.
-
Abstract
- Mineralocorticoid receptor (MR) antagonists have been clinically used to treat heart failure. However, the underlying cellular and molecular mechanisms remain incompletely understood.Using osteoblast MR knockout (MRMR deficiency in osteoblasts alleviates pathological ventricular remodeling after MI, likely through its regulation on OCN. Spironolactone may work through osteoblast MR/OCN axis to exert its therapeutic effects on pathological ventricular remodeling and heart failure in mice and human patients.
Details
- ISSN :
- 00222828
- Volume :
- 167
- Database :
- OpenAIRE
- Journal :
- Journal of Molecular and Cellular Cardiology
- Accession number :
- edsair.doi.dedup.....1e735195b71d2ff035d4674b66dd9ec0