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Synergistic retention strategy of RGD active targeting and radiofrequency-enhanced permeability for intensified RF & chemotherapy synergistic tumor treatment
- Source :
- Biomaterials. 99:34-46
- Publication Year :
- 2016
- Publisher :
- Elsevier BV, 2016.
-
Abstract
- Despite gaining increasing attention, chelation of multiple active targeting ligands greatly increase the formation probability of protein corona, disabling active targeting. To overcome it, a synergistic retention strategy of RGD-mediated active targeting and radiofrequency (RF) electromagnetic field-enhanced permeability has been proposed here. It is validated that such a special synergistic retention strategy can promote more poly lactic-co-glycolic acid (PLGA)-based capsules encapsulating camptothecin (CPT) and solid DL-menthol (DLM) to enter and retain in tumor in vitro and in vivo upon exposure to RF irradiation, receiving an above 8 fold enhancement in HeLa retention. Moreover, the PLGA-based capsules can respond RF field to trigger the entrapped DLM to generate solid-liquid-gas (SLG) tri-phase transformation for enhancing RF ablation and CPT release. Therefore, depending on the enhanced RF ablation and released CPT and the validated synergistic retention effect, the inhibitory outcome for tumor growth has gained an over 10-fold improvement, realizing RF ablation & chemotherapy synergistic treatment against HeLa solid tumor, which indicates a significant promise in clinical RF ablation.
- Subjects :
- medicine.medical_treatment
Protein Corona
02 engineering and technology
01 natural sciences
HeLa
chemistry.chemical_compound
Drug Delivery Systems
Polylactic Acid-Polyglycolic Acid Copolymer
biology
021001 nanoscience & nanotechnology
Combined Modality Therapy
Menthol
PLGA
Mechanics of Materials
0210 nano-technology
Oligopeptides
Rf ablation
medicine.drug
Materials science
Cell Survival
Surface Properties
Biophysics
Mice, Nude
Antineoplastic Agents
Bioengineering
010402 general chemistry
Permeability
Biomaterials
medicine
Animals
Humans
Chelation
Lactic Acid
Cell Proliferation
Fluorescent Dyes
Chemotherapy
biology.organism_classification
Pulsed Radiofrequency Treatment
Rats
0104 chemical sciences
Drug Liberation
chemistry
Permeability (electromagnetism)
Ceramics and Composites
Camptothecin
Neoplasm Transplantation
Polyglycolic Acid
HeLa Cells
Biomedical engineering
Subjects
Details
- ISSN :
- 01429612
- Volume :
- 99
- Database :
- OpenAIRE
- Journal :
- Biomaterials
- Accession number :
- edsair.doi.dedup.....1e755efa7971fb67a4a7c83faf65a13e