Back to Search
Start Over
Systemic Inflammation and COVID-19 Mortality in Patients with Major Noncommunicable Diseases: Chronic Coronary Syndromes, Diabetes and Obesity
- Source :
- Journal of Clinical Medicine, Journal of Clinical Medicine, Vol 10, Iss 1545, p 1545 (2021)
- Publication Year :
- 2021
- Publisher :
- MDPI AG, 2021.
-
Abstract
- COVID-19 is currently considered an inflammatory disease affecting the entire organism. In severe forms, an augmented inflammatory response leads to the fulminant “cytokine storm”, which may result in severe multisystemic end-organ damage. Apart from the acute inflammatory response, it seems that chronic inflammation also plays a major role in the clinical evolution of COVID-19 patients. Pre-existing inflammatory conditions, such as those associated with chronic coronary diseases, type 2 diabetes mellitus or obesity, may be associated with worse clinical outcomes in the context of COVID-19 disease. These comorbidities are reported as powerful predictors of poor outcomes and death following COVID-19 disease. Moreover, in the context of chronic coronary syndrome, the cytokine storm triggered by SARS-CoV-2 infection may favor vulnerabilization and rupture of a silent atheromatous plaque, with consequent acute coronary syndrome, leading to a sudden deterioration of the clinical condition of the patient. This review aims to present the current status of knowledge regarding the link between COVID-19 mortality, systemic inflammation and several major diseases associated with poor outcomes, such as cardiovascular diseases, diabetes and obesity.
- Subjects :
- obesity
medicine.medical_specialty
Acute coronary syndrome
Fulminant
lcsh:Medicine
Review
Disease
Type 2 diabetes
030204 cardiovascular system & hematology
Systemic inflammation
03 medical and health sciences
0302 clinical medicine
Diabetes mellitus
Internal medicine
Medicine
030304 developmental biology
chronic coronary syndrome
0303 health sciences
business.industry
lcsh:R
Type 2 Diabetes Mellitus
General Medicine
medicine.disease
inflammation
cytokine storm
type 2 diabetes
medicine.symptom
business
Cytokine storm
Subjects
Details
- ISSN :
- 20770383
- Volume :
- 10
- Database :
- OpenAIRE
- Journal :
- Journal of Clinical Medicine
- Accession number :
- edsair.doi.dedup.....1e7921326de1bdb5461da3a1e61b65d6