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Immunoglobulin inclusions in non-Hodgkin's lymphomas
- Source :
- American journal of clinical pathology. 69(3)
- Publication Year :
- 1978
-
Abstract
- The occurrence and characteristics of intracellular immunoglobulin inclusions in non-Hodgkin’s lymphomas are described. Lymphoma cells from three patients with immunoblastic sarcoma contained classic cytoplasmic, periodic acid-Schiff (PAS)-positive Russell bodies. Immunoperoxidase staining revealed monoclonal IgG ( k ) in two cases and a polyclonal pattern in the third case, where the tumor evolved from a reactive lesion. Unusual cytoplasmic inclusions were observed in the neoplastic cells of two patients with follicular center cell lymphoma. In one case large globular structures lacking a distinct limiting membrane were seen, while the cells of the other patient contained “signet-ring-like” vacuoles filled with microvesicles. Both were PAS-negative and showed monoclonal immunoglobulin staining. In two other cases PAS-positive intranuclear inclusions consisting of monoclonal immunoglobulin IgM(κ) could be demonstrated. The possible significance of these findings in B-lymphocyte derived neoplasms is discussed.
- Subjects :
- Adult
Male
Pathology
medicine.medical_specialty
Cytoplasm
Lymphoma
Cytoplasmic inclusion
Russell bodies
Immunoglobulins
medicine
Humans
Aged
Inclusion Bodies
biology
Immunoperoxidase
Histocytochemistry
Sarcoma
General Medicine
Middle Aged
medicine.disease
Staining
Immunoglobulin M
Polyclonal antibodies
biology.protein
Female
Lymph Nodes
Antibody
Subjects
Details
- ISSN :
- 00029173
- Volume :
- 69
- Issue :
- 3
- Database :
- OpenAIRE
- Journal :
- American journal of clinical pathology
- Accession number :
- edsair.doi.dedup.....1e8a755e9ba72fe03f12d50c094ab288