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An investigation of the effect of the prostaglandin EP2 receptor agonist, butaprost, on the human isolated myometrium from pregnant and non-pregnant women
- Source :
- Journal of Endocrinology. 172:263-269
- Publication Year :
- 2002
- Publisher :
- Bioscientifica, 2002.
-
Abstract
- The aim of this study was to compare the effect of two known spasmogens, oxytocin and the stable thromboxane receptor mimetic, U46619, on human myometrium treated with the prostaglandin E receptor (EP2) agonist, butaprost (selective for the EP2 receptor). Strips of myometrium from pregnant and non-pregnant donors were set up in a superfusion apparatus. Butaprost was administered as a bolus dose and via infusion. During the infusion of 10(-6) M butaprost, spasmogens were administered as bolus doses. Butaprost caused dose-related inhibition of myometrial activity when administered as a bolus dose (3-100 nmol) and concentration-dependent inhibition during infusion studies (10(-8)-10(-5 )M). Butaprost (10(-6 )M) attenuated the response to U46619 (0.l-10 nmol) in pregnant myometrium, but this difference was not statistically significant. Responses of pregnant myometrium to oxytocin (0.01-0.1 nmol) were significantly attenuated (P
- Subjects :
- Agonist
medicine.medical_specialty
medicine.drug_class
Endocrinology, Diabetes and Metabolism
In Vitro Techniques
Oxytocin
Thromboxane receptor
Uterine Contraction
chemistry.chemical_compound
Endocrinology
Pregnancy
Internal medicine
medicine
Humans
Receptors, Prostaglandin E
Alprostadil
Receptor
Analysis of Variance
Dose-Response Relationship, Drug
Chemistry
Myometrium
Parasympatholytics
Prostanoid
musculoskeletal system
Tocolytic Agents
15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid
Depression, Chemical
Prostaglandin EP2 receptor
Female
Antagonism
medicine.drug
Subjects
Details
- ISSN :
- 14796805 and 00220795
- Volume :
- 172
- Database :
- OpenAIRE
- Journal :
- Journal of Endocrinology
- Accession number :
- edsair.doi.dedup.....1e8cff46fea6ba977ecfd8e7e359f327