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Biochemical mechanisms of vertebrate hedgehog signaling

Authors :
Kong, J
Siebold, C
Rohatgi, R
Source :
Development
Publication Year :
2019
Publisher :
The Company of Biologists, 2019.

Abstract

Signaling pathways that mediate cell-cell communication are essential for collective cell behaviors in multicellular systems. The hedgehog (HH) pathway, first discovered and elucidated in Drosophila, is one of these iconic signaling systems that plays many roles during embryogenesis and in adults; abnormal HH signaling can lead to birth defects and cancer. We review recent structural and biochemical studies that have advanced our understanding of the vertebrate HH pathway, focusing on the mechanisms by which the HH signal is received by patched on target cells, transduced across the cell membrane by smoothened, and transmitted to the nucleus by GLI proteins to influence gene-expression programs.

Details

ISSN :
14779129 and 09501991
Volume :
146
Database :
OpenAIRE
Journal :
Development
Accession number :
edsair.doi.dedup.....1e9feed2f1812aabf2eb228288117fad