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Biochemical mechanisms of vertebrate hedgehog signaling
- Source :
- Development
- Publication Year :
- 2019
- Publisher :
- The Company of Biologists, 2019.
-
Abstract
- Signaling pathways that mediate cell-cell communication are essential for collective cell behaviors in multicellular systems. The hedgehog (HH) pathway, first discovered and elucidated in Drosophila, is one of these iconic signaling systems that plays many roles during embryogenesis and in adults; abnormal HH signaling can lead to birth defects and cancer. We review recent structural and biochemical studies that have advanced our understanding of the vertebrate HH pathway, focusing on the mechanisms by which the HH signal is received by patched on target cells, transduced across the cell membrane by smoothened, and transmitted to the nucleus by GLI proteins to influence gene-expression programs.
- Subjects :
- Patched
Cell
Review
Biology
03 medical and health sciences
0302 clinical medicine
medicine
Animals
Humans
Hedgehog Proteins
Molecular Biology
Hedgehog
030304 developmental biology
0303 health sciences
Hedgehog signaling pathway
3. Good health
Cell biology
Multicellular organism
medicine.anatomical_structure
Vertebrates
Signal transduction
Smoothened
030217 neurology & neurosurgery
Signal Transduction
Developmental Biology
Morphogen
Subjects
Details
- ISSN :
- 14779129 and 09501991
- Volume :
- 146
- Database :
- OpenAIRE
- Journal :
- Development
- Accession number :
- edsair.doi.dedup.....1e9feed2f1812aabf2eb228288117fad