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Highly Sensitive HBsAg, Anti-HBc and Anti HBsAg Titres in Early Diagnosis of HBV Reactivation in Anti-HBc-Positive Onco-Haematological Patients
- Source :
- Biomedicines; Volume 10; Issue 2; Pages: 443
- Publication Year :
- 2022
- Publisher :
- Multidisciplinary Digital Publishing Institute, 2022.
-
Abstract
- The role of novel HBV markers in predicting Hepatitis B virus reactivation (HBV-R) in HBsAg-negative/anti-HBc-positive oncohaematological patients was examined. One hundred and seven HBsAg-negative/anti-HBc-positive oncohaematological patients, receiving anti-HBV prophylaxis for > 18 months were included. At baseline, all patients had undetectable HBV DNA, and 67.3% were anti-HBs positive. HBV-R occurred in 17 (15.9%) patients: 6 during and 11 after the prophylaxis period. At HBV-R, the median (IQR) HBV-DNA was 44 (27–40509) IU/ml, and the alanine aminotransferase upper limit of normal (ULN) was 44% (median [IQR]: 81[49–541] U/L). An anti-HBc>3 cut-off index (COI) plus anti-HBs persistently/declining to 2 time points, also predicts HBV-R (OR [95% CI ]: 13.8 [3.6–52.6]; 50% of positive vs. 7% of negative patients to these markers experienced HBV-R, P=0.001).HS-HBs and anti-HBc titration proved useful early markers of HBV-R.The use of these markers demonstrated that HBV-R frequently occurs in oncohaematological patients with signs of resolved HBV infection, raising issues of proper HBV-R monitoring.
- Subjects :
- HBsAg
business.industry
antiviral prophylaxis
Hbv reactivation
HBV reactivation
Medicine (miscellaneous)
virus diseases
resolved HBV infection
Virology
General Biochemistry, Genetics and Molecular Biology
digestive system diseases
Highly sensitive
Settore MED/07
Anti hbc
new HBV markers
HSCT
oncohaematological patients
Medicine
anti-HBc positivity
business
Subjects
Details
- Language :
- English
- ISSN :
- 22279059
- Database :
- OpenAIRE
- Journal :
- Biomedicines; Volume 10; Issue 2; Pages: 443
- Accession number :
- edsair.doi.dedup.....1ea1e4a25b324c9bf9548b3446676d70
- Full Text :
- https://doi.org/10.3390/biomedicines10020443