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Cortico-Striatal GABAergic and Glutamatergic Dysregulations in Subjects at Ultra-High Risk for Psychosis Investigated with Proton Magnetic Resonance Spectroscopy
- Source :
- International Journal of Neuropsychopharmacology
- Publication Year :
- 2015
- Publisher :
- Oxford University Press (OUP), 2015.
-
Abstract
- Background: Dysregulations of the major inhibitory and excitatory amino neurotransmitter systems of γ-aminobutyric acid and glutamate, respectively, have been described in patients with schizophrenia. However, it is unclear whether these abnormalities are present in subjects at ultra-high risk for psychosis. Methods: Twenty-three antipsychotic naive subjects at ultra-high risk and 24 healthy control subjects, matched for age, sex, handedness, cigarette smoking, and parental education, underwent proton magnetic resonance spectroscopy scans in the dorsal caudate bilaterally and the medial prefrontal cortex at 3T. Levels of γ-aminobutyric acid and of the combined resonance of glutamate and glutamine (Glx) were obtained using the standard J-editing technique and expressed as peak area ratios relative to the synchronously acquired unsuppressed voxel water signal. Results: Higher levels of γ-aminobutyric acid ( P
- Subjects :
- Male
Risk
Psychosis
medicine.medical_specialty
Proton Magnetic Resonance Spectroscopy
Glutamic Acid
Prefrontal Cortex
Prodromal Symptoms
glutamate
ultra-high risk
gamma-Aminobutyric acid
Young Adult
GABA
03 medical and health sciences
Glutamatergic
chemistry.chemical_compound
0302 clinical medicine
1H MRS
Internal medicine
Interview, Psychological
medicine
Humans
Genetic Predisposition to Disease
Pharmacology (medical)
psychosis
Neurotransmitter
Prefrontal cortex
gamma-Aminobutyric Acid
Pharmacology
Glutamate receptor
medicine.disease
Corpus Striatum
030227 psychiatry
schizophrenia
Glutamine
Psychiatry and Mental health
Endocrinology
Psychotic Disorders
chemistry
Schizophrenia
Linear Models
Female
Psychology
Neuroscience
030217 neurology & neurosurgery
Research Article
medicine.drug
Subjects
Details
- ISSN :
- 14695111 and 14611457
- Volume :
- 19
- Database :
- OpenAIRE
- Journal :
- International Journal of Neuropsychopharmacology
- Accession number :
- edsair.doi.dedup.....1ec453126bdae279f1c946450e24d594