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Evaluation of canine left ventricular contractility
- Source :
- Cardiovascular Research. 8:313-322
- Publication Year :
- 1974
- Publisher :
- Oxford University Press (OUP), 1974.
-
Abstract
- After exposure of the hearts of eight dogs to a total of 45 min of myocardial ischaemia during cardiopulmonary bypass, mean left ventricular hydraulic output power (MLVP) decreased to an average of 49·5% of the original value and Vmax to 95·2% of its original value. During a constant intravenous infusion of isoproterenol, MLVP and Vmax expressed as a percentage of the depressed value noted after ischaemia, increased to an average of 229 and 164%, respectively. During epinephrine infusion MLVP and Vmax increased to an average of 171 and 123%, respectively, relative to the post-ischaemic levels. MLVP was shown to quantitate practically all of the mechanical output power of the left ventricle. Thus, if preload, afterload, and heart rate are controlled, MLVP should be representative of the contractile state of the left ventricle. Since changes of Vmax in response to positive and negative inotropic intervention did not correlate with MLVP, we concluded Vmax did not accurately reflect quantitative change of the contractile state of the left ventricle.
- Subjects :
- Inotrope
Extracorporeal Circulation
medicine.medical_specialty
Epinephrine
Physiology
Heart Ventricles
Coronary Disease
law.invention
Dogs
Afterload
Ischemia
law
Physiology (medical)
Internal medicine
Infusion Procedure
Heart rate
medicine
Cardiopulmonary bypass
Animals
Cardiac Output
business.industry
Isoproterenol
Heart
Organ Size
Preload
medicine.anatomical_structure
Ventricle
Anesthesia
Cardiology
Vascular Resistance
Cardiology and Cardiovascular Medicine
business
medicine.drug
Subjects
Details
- ISSN :
- 00086363
- Volume :
- 8
- Database :
- OpenAIRE
- Journal :
- Cardiovascular Research
- Accession number :
- edsair.doi.dedup.....1ecaadb9b494ecaef8255d46144a1ca1