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Muscle mass and grip strength in relation to carotid intima-media thickness and plaque score in patients with type 2 diabetes
Muscle mass and grip strength in relation to carotid intima-media thickness and plaque score in patients with type 2 diabetes
- Source :
- Nutrition, Metabolism and Cardiovascular Diseases. 31:2935-2944
- Publication Year :
- 2021
- Publisher :
- Elsevier BV, 2021.
-
Abstract
- In this study, we examined the relationships of appendicular skeletal muscle mass (ASM) and grip strength (GS) with carotid intima-media thickness (CIMT) and plaque score (PS) in patients with type 2 diabetes.A total of 1185 patients were recruited. High CIMT and high PS were defined as ≥ 75 percentile of maximal CIMT of each sex and PS ≥ 3. Patients in the lowest ASM/body mass index (BMI) or GS/BMI tertile were older and had lower HDL cholesterol, and eGFR, but higher BMI, waist circumference (WC), HOMA-IR, and C-reactive protein than those in the highest tertile. Meanwhile, individuals in the lowest ASM or GS tertile group had lower BMI and WC than those in the highest one. CIMT and PS and the prevalence of high CIMT, carotid plaques, and high PS gradually increased with decreasing tertiles of ASM, ASM/BMI, GS, and GS/BMI (p 0.001). After adjusting for age and sex, odds ratios (ORs) and 95% confidence intervals (CIs) for high CIMT and high PS were 0.98 (0.68-1.42), 1.64 (1.14-2.36), 2.000 (1.33-3.01), and 1.77 (1.22-2.58) and 1.63 (1.16-2.30), 1.78 (1.28-2.54), 1.91 (1.33-2.75), and 1.61 (1.13-2.28) in the lowest tertile of ASM, ASM/BMI, GS, and GS/BMI, respectively. After further adjusting for potential confounders, ORs and 95% CI for high CIMT and high PS remained significant in the lowest tertile group.Low ASM and low GS may be independent risk factors for high CIMT and high PS in patients with type 2 diabetes.
- Subjects :
- Carotid Artery Diseases
Male
Sarcopenia
Percentile
medicine.medical_specialty
Waist
Endocrinology, Diabetes and Metabolism
Medicine (miscellaneous)
Type 2 diabetes
Carotid Intima-Media Thickness
Risk Assessment
Body Mass Index
chemistry.chemical_compound
Grip strength
Absorptiometry, Photon
Predictive Value of Tests
Risk Factors
Internal medicine
Republic of Korea
Prevalence
Humans
Medicine
In patient
cardiovascular diseases
Muscle, Skeletal
Aged
Nutrition and Dietetics
Hand Strength
business.industry
Cholesterol
nutritional and metabolic diseases
Middle Aged
respiratory system
musculoskeletal system
medicine.disease
Plaque, Atherosclerotic
Cross-Sectional Studies
Diabetes Mellitus, Type 2
Intima-media thickness
chemistry
Body Composition
cardiovascular system
Cardiology
Female
Cardiology and Cardiovascular Medicine
business
Body mass index
Subjects
Details
- ISSN :
- 09394753
- Volume :
- 31
- Database :
- OpenAIRE
- Journal :
- Nutrition, Metabolism and Cardiovascular Diseases
- Accession number :
- edsair.doi.dedup.....1ecabb7820e009e34f6218aad84e1b1b
- Full Text :
- https://doi.org/10.1016/j.numecd.2021.07.016