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Dibenzocyclooctadiene lignans from Kadsura heteroclita
- Source :
- Fitoterapia. 119:150-157
- Publication Year :
- 2017
- Publisher :
- Elsevier BV, 2017.
-
Abstract
- Sixteen dibenzocyclooctadiene lignans, including eight new ones, kadheterins A-H (1-8), and a new natural product, 9-benzoyloxy-gomisin B (9), were isolated from the stems of K. heteroclita. The structures of 1-9 were elucidated by extensive spectroscopic methods, and their absolute configurations were determined by combining CD with ROESY experiments. Additionally, the absolute configuration of 1 was further confirmed by single crystal X-ray crystallographic analysis. In vitro activity assays showed that 1 exhibited moderate cytotoxicity against HL-60 with IC50 value at 14.59μM.
- Subjects :
- Stereochemistry
HL-60 Cells
Nitric Oxide
01 natural sciences
Lignans
Cyclooctanes
Mice
chemistry.chemical_compound
Kadsura
Cell Line, Tumor
Drug Discovery
Animals
Humans
Pharmacology
Natural product
Molecular Structure
Plant Stems
010405 organic chemistry
Chemistry
Macrophages
Absolute configuration
General Medicine
0104 chemical sciences
010404 medicinal & biomolecular chemistry
RAW 264.7 Cells
Kadsura heteroclita
Subjects
Details
- ISSN :
- 0367326X
- Volume :
- 119
- Database :
- OpenAIRE
- Journal :
- Fitoterapia
- Accession number :
- edsair.doi.dedup.....1ed515df6fa62f3624bc3fdd23eddbce