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Local Translation in Axons: When Membraneless RNP Granules Meet Membrane-Bound Organelles
- Source :
- Frontiers in Molecular Biosciences, Frontiers in Molecular Biosciences, 2019, 6, ⟨10.3389/fmolb.2019.00129⟩, Frontiers in Molecular Biosciences, Vol 6 (2019), Frontiers in Molecular Biosciences, Frontiers Media, 2019, 6, ⟨10.3389/fmolb.2019.00129⟩, Frontiers in Molecular Biosciences, 2019, 6, pp.129. ⟨10.3389/fmolb.2019.00129⟩, Frontiers in Molecular Biosciences, Frontiers Media, 2019, 6, pp.129. ⟨10.3389/fmolb.2019.00129⟩
- Publication Year :
- 2019
- Publisher :
- HAL CCSD, 2019.
-
Abstract
- International audience; Eukaryotic cell compartmentalization relies on long-known membrane-delimited organelles, as well as on more recently discovered membraneless macromolecular condensates. How these two types of organelles interact to regulate cellular functions is still largely unclear. In this review, we highlight how membraneless ribonucleoprotein (RNP) organelles, enriched in RNAs and associated regulatory proteins, cooperate with membrane-bound organelles for tight spatio-temporal control of gene expression in the axons of neuronal cells. Specifically, we present recent evidence that motile membrane-bound organelles are used as vehicles by RNP cargoes, promoting the long-range transport of mRNA molecules to distal axons. As demonstrated by recent work, membrane-bound organelles also promote local protein synthesis, by serving as platforms for the local translation of mRNAs recruited to their outer surface. Furthermore, dynamic and specific association between RNP cargoes and membrane-bound organelles is mediated by bi-partite adapter molecules that interact with both types of organelles selectively, in a regulated-manner. Maintaining such a dynamic interplay is critical, as alterations in this process are linked to neurodegenerative diseases. Together, emerging studies thus point to the coordination of membrane-bound and membraneless organelles as an organizing principle underlying local cellular responses.
- Subjects :
- 0301 basic medicine
[SDV]Life Sciences [q-bio]
RNA transport
Review
Mitochondrion
Biochemistry, Genetics and Molecular Biology (miscellaneous)
Biochemistry
03 medical and health sciences
0302 clinical medicine
local translation
Gene expression
Organelle
medicine
Protein biosynthesis
Molecular Biosciences
Axon
Molecular Biology
lcsh:QH301-705.5
Ribonucleoprotein
axon
Messenger RNA
RNP granules
Chemistry
Cell biology
mitochondria
[SDV] Life Sciences [q-bio]
030104 developmental biology
medicine.anatomical_structure
lcsh:Biology (General)
030220 oncology & carcinogenesis
vesicular trafficking
Subjects
Details
- Language :
- English
- ISSN :
- 2296889X
- Database :
- OpenAIRE
- Journal :
- Frontiers in Molecular Biosciences, Frontiers in Molecular Biosciences, 2019, 6, ⟨10.3389/fmolb.2019.00129⟩, Frontiers in Molecular Biosciences, Vol 6 (2019), Frontiers in Molecular Biosciences, Frontiers Media, 2019, 6, ⟨10.3389/fmolb.2019.00129⟩, Frontiers in Molecular Biosciences, 2019, 6, pp.129. ⟨10.3389/fmolb.2019.00129⟩, Frontiers in Molecular Biosciences, Frontiers Media, 2019, 6, pp.129. ⟨10.3389/fmolb.2019.00129⟩
- Accession number :
- edsair.doi.dedup.....1ee4cf42964520f22571fed5f094fb8c