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A novel TNM staging system for gastric cancer based on the metro-ticket paradigm: a comparative study with the AJCC-TNM staging system
- Source :
- Gastric Cancer. 22:759-768
- Publication Year :
- 2019
- Publisher :
- Springer Science and Business Media LLC, 2019.
-
Abstract
- The metro-ticket prognostic tool for hepatocellular carcinoma has been proven to predict outcome, but a similar concept has not been investigated for GC. The objective of the current study was to apply the principles of the metro-ticket paradigm to develop a novel TNM staging system (nTNM) for gastric cancer (GC). The nTNM considered the distance from the origin on a Cartesian plane incorporating the pN (x-axis) and pT (y-axis) stages. GC patients undergoing radical resection at Fujian Medical University Union Hospital (FMUUH) (n = 4267) were included. The nTNM was validated using 2 external cohorts from the Sun Yat-sen University Cancer Center (SYSUCC) (n = 1800) and Surveillance, Epidemiology, and End Results (SEER) (n = 3227) databases. nTNM classes with the same distance from the origin have same stage; the stage increases with this distance. Among all patients, 48.0% (n = 2049) were restaged in the nTNM compared with the 7th edition of the AJCC-TNM classification; 26.2% (n = 1116) were downstaged in the nTNM compared with the 8th edition. The nTNM provides significant survival differences between stages (all P
- Subjects :
- Male
End results
Oncology
Cancer Research
medicine.medical_specialty
Databases, Factual
TNM staging system
03 medical and health sciences
0302 clinical medicine
Gastrectomy
Stomach Neoplasms
Internal medicine
Epidemiology
medicine
Humans
Stage (cooking)
Neoplasm Staging
Retrospective Studies
business.industry
Hazard ratio
Gastroenterology
Cancer
General Medicine
Middle Aged
Prognosis
medicine.disease
Survival Rate
030220 oncology & carcinogenesis
Hepatocellular carcinoma
Female
030211 gastroenterology & hepatology
Radical resection
business
Follow-Up Studies
SEER Program
Subjects
Details
- ISSN :
- 14363305 and 14363291
- Volume :
- 22
- Database :
- OpenAIRE
- Journal :
- Gastric Cancer
- Accession number :
- edsair.doi.dedup.....1ee4f88bcfbd467778fde839eb2efbd9