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Effects of Levosimendan on Endothelial Function and Hemodynamics During Weaning From Veno-Arterial Extracorporeal Life Support
- Source :
- Journal of cardiothoracic and vascular anesthesia. 30(6)
- Publication Year :
- 2016
-
Abstract
- Objective Weaning from veno-arterial extracorporeal life support is challenging. The objective of this trial was to investigate the endothelial and hemodynamic effects of levosimendan in cardiogenic shock patients supported with veno-arterial extracorporeal life support. Design This was a prospective observational trial. Setting Cardiovascular intensive care unit of a large tertiary care university hospital in Monza, Italy. Participants and Interventions Flow-mediated dilatation of the brachial artery and hemodynamic parameters were assessed in 10 cardiogenic shock patients supported with veno-arterial extracorporeal life support, before and after the infusion of levosimendan. Measurements and Results Flow-mediated dilatation increased both as absolute value and as a percentage after levosimendan, from 0.10±0.12 to 0.61±0.21 mm (p
- Subjects :
- Male
Vasodilator Agents
Hemodynamics
030204 cardiovascular system & hematology
extracorporeal life support
law.invention
0302 clinical medicine
endothelial function
law
Prospective Studies
Brachial artery
Cardiac Output
Aged, 80 and over
Cardiogenic shock
cardiogenic shock
Middle Aged
Intensive care unit
Pyridazines
Vasodilation
Cardiology
Female
ECMO
Cardiology and Cardiovascular Medicine
Ventilator Weaning
medicine.drug
Adult
medicine.medical_specialty
Shock, Cardiogenic
Extracorporeal
03 medical and health sciences
levosimendan
Extracorporeal Membrane Oxygenation
hemodynamic
Internal medicine
medicine.artery
medicine
Weaning
Humans
Simendan
Aged
business.industry
Hydrazones
030208 emergency & critical care medicine
Levosimendan
medicine.disease
Oxygen
Anesthesiology and Pain Medicine
Life support
Endothelium, Vascular
business
Subjects
Details
- ISSN :
- 15328422
- Volume :
- 30
- Issue :
- 6
- Database :
- OpenAIRE
- Journal :
- Journal of cardiothoracic and vascular anesthesia
- Accession number :
- edsair.doi.dedup.....1eebbedd3a9420d22b7ff405bb2da20e