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Mortality experiences among 15+ year survivors of childhood and adolescent cancers
- Source :
- Pediatric Blood & Cancer. 48:333-338
- Publication Year :
- 2007
- Publisher :
- Wiley, 2007.
-
Abstract
- Background Studies of childhood and adolescent cancer survivorship have tended to focus on limited survival intervals (e.g., 5 and 10 years). Our report evaluates gender-specific overall mortality, as well as mortality by age group, and by cause, among 15+ year survivors of cancer diagnosed during childhood or adolescence. Procedure This was a retrospective cohort study of 565 15+ year childhood cancer survivors from Roswell Park Cancer Institute's Long-Term Follow-Up Project. Sex- and age-specific person-years at risk were accumulated and applied to age-specific mortality rates for New York State, excluding New York City. Standardized mortality ratios (SMRs), and 95% confidence intervals, were calculated and compared to mortality risks of the general population. Results Second malignancy was the leading cause of death among male and female survivors (15/38 deaths, 39%). Excess overall mortality was noted among both males (SMR = 284) and females (SMR = 371). Significant mortality excesses were seen in both genders for deaths due to primary malignant neoplasms and secondary malignancies, as well as cardiac deaths among males. Excess mortality was noted across most age strata. In the scenario of no cancer relapse, overall mortality in both genders did not differ significantly from the general population. Conclusions Long-term survivors of childhood and adolescent cancers continue to demonstrate significant excess mortality. However, overall mortality among 15+ year survivors without a relapse appears to be comparable to the general population. The leading cause of death among 15+ year survivors is second malignancy in this study, which represents a novel and important finding in terms of long-term follow-up. Pediatr Blood Cancer 2007;48:333–338. © 2006 Wiley-Liss, Inc.
- Subjects :
- Male
Pediatrics
medicine.medical_specialty
Time Factors
Adolescent
Heart Diseases
Population
Therapeutics
Cohort Studies
Neoplasms, Multiple Primary
Cause of Death
Neoplasms
Survivorship curve
medicine
Humans
Survivors
Child
education
Retrospective Studies
Cause of death
education.field_of_study
business.industry
Mortality rate
Remission Induction
Infant
Cancer
Neoplasms, Second Primary
Retrospective cohort study
Hematology
medicine.disease
Confidence interval
Oncology
Child, Preschool
Pediatrics, Perinatology and Child Health
Female
business
Cohort study
Subjects
Details
- ISSN :
- 15455017 and 15455009
- Volume :
- 48
- Database :
- OpenAIRE
- Journal :
- Pediatric Blood & Cancer
- Accession number :
- edsair.doi.dedup.....1eef9a35598e1c9836a4169efde4f02b