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Epicutaneous exposure to staphylococcal superantigen enterotoxin B enhances allergic lung inflammation via an IL-17A dependent mechanism
- Source :
- PLoS ONE, PLoS ONE, Vol 7, Iss 7, p e39032 (2012)
- Publication Year :
- 2012
-
Abstract
- Atopic dermatitis (AD) is the initial step of the atopic march: the progression from AD to allergic rhinitis and asthma. There is a close association between skin barrier abnormalities and the development of AD and the atopic march. One of cardinal features of AD is that the lesional skin of the majority of AD patients is chronically colonized with Staphylococcus aureus with half isolates producing superantigen enterotoxin B (SEB). Although diverse roles of SEB in the pathogenesis and severity of AD have been recognized, whether SEB contributes to the dermal inflammation that drives lung inflammation and airway hyperresponsiveness (AHR) has not been examined. Here we show a novel role of S. aureus superantigen SEB in augmenting allergen ovalbumin (Ova) induced atopic march through an IL-17A dependent mechanism. When mice epicutaneously (EC) sensitized with allergen Ova, addition of topical SEB led to not only augmented systemic Th2 responses but also a markedly exaggerated systemic Th17/IL-17 immune environment. The ability of SEB in enhancing Th17/IL-17 was mediated through stimulating lymphocytes in spleen and draining lymph nodes to promote IL-6 production. Epicutaneous sensitization of mice with a combination of Ova and SEB significantly enhanced Ova-induced AHR and granulocytic lung inflammation than Ova allergen alone. When IL-17A was deleted genetically, the effects of SEB on augmenting lung inflammation and AHR were markedly diminished. These findings suggest that chronic heavy colonization of enterotoxin producing S. aureus in the skin of patients with atopic dermatitis may have an important role in the development of atopic march via an IL-17A dependent mechanism.
- Subjects :
- Anatomy and Physiology
Mouse
Pulmonology
lcsh:Medicine
Atopic Dermatitis
Enterotoxin
medicine.disease_cause
Pathogenesis
Enterotoxins
Mice
0302 clinical medicine
Allergen
Superantigen
lcsh:Science
Lung
Skin
0303 health sciences
Mice, Inbred BALB C
Multidisciplinary
biology
Allergy and Hypersensitivity
Interleukin-17
hemic and immune systems
Atopic dermatitis
Animal Models
respiratory system
Bacterial Pathogens
Medicine
Staphylococcal Skin Infections
medicine.symptom
Research Article
Staphylococcus aureus
Immunology
Inflammation
chemical and pharmacologic phenomena
Dermatology
Microbiology
Dermatitis, Atopic
Immunomodulation
03 medical and health sciences
Immune system
Th2 Cells
Model Organisms
medicine
Respiratory Hypersensitivity
Animals
Humans
Biology
030304 developmental biology
Gram Positive
business.industry
Interleukin-6
lcsh:R
Immunity
Pneumonia
medicine.disease
biological factors
Asthma
Ovalbumin
030228 respiratory system
biology.protein
Th17 Cells
lcsh:Q
Clinical Immunology
business
Subjects
Details
- ISSN :
- 19326203
- Volume :
- 7
- Issue :
- 7
- Database :
- OpenAIRE
- Journal :
- PloS one
- Accession number :
- edsair.doi.dedup.....1ef0bc13e5e8a1a98e1ca0ee7999c94a