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Creation of an Open-Access, Mutation-Defined Fibroblast Resource for Neurological Disease Research

Authors :
Wray, S
Self, M
NINDS Parkinson's Disease iPSC Consortium
Gusella, NINDS Huntington's Disease iPSC Consortium James F.
Macdonald, Marcy E.
Wheeler, Vanessa C.
Ross, Christopher A.
Sergey, Akimov
Jamshid, Arjomand
Thompson, Leslie M.
Alvin, King
Neal, Hermanowicz
Sara, Winokur
Svendsen, Clive N.
Virginia, Mattis
Onorati, Marco
Elena, Cattaneo
Allen, Nicholas D.
Kemp, Paul J.
Kwang Soo Kim
Steven, Finkbeiner
NINDS ALS iPSC Consortium
Lewis, Pa
Taanman, Jw
Ryan, Ns
Mahoney, Cj
Liang, Y
Devine, Mj
Sheerin, Um
Houlden, H
Morris, Hr
Healy, D
Marti Masso JF
Preza, E
Barker, S
Sutherland, M
Corriveau, Ra
D'Andrea, M
Schapira, Ah
Uitti, Rj
Guttman, M
Opala, G
Jasinska Myga, B
Puschmann, A
Nilsson, C
Espay, Aj
Slawek, J
Gutmann, L
Boeve, Bf
Boylan, K
Stoessl, Aj
Ross, Oa
Maragakis, Nj
Van Gerpen, J
Gerstenhaber, M
Gwinn, K
Dawson, Tm
Isacson, O
Marder, Ks
Clark, Ln
Przedborski, Se
Finkbeiner, S
Rothstein, Jd
Wszolek, Zk
Rossor, Mn
Hardy, J.
Borlongan, Cesar V
Source :
PLoS ONE, PLoS ONE; 7(8) (2012), PloS one, vol 7, iss 8, PLoS ONE, Vol 7, Iss 8, p e43099 (2012)
Publication Year :
2012
Publisher :
Public Library of Science (PLoS), 2012.

Abstract

Our understanding of the molecular mechanisms of many neurological disorders has been greatly enhanced by the discovery of mutations in genes linked to familial forms of these diseases. These have facilitated the generation of cell and animal models that can be used to understand the underlying molecular pathology. Recently, there has been a surge of interest in the use of patient-derived cells, due to the development of induced pluripotent stem cells and their subsequent differentiation into neurons and glia. Access to patient cell lines carrying the relevant mutations is a limiting factor for many centres wishing to pursue this research. We have therefore generated an open-access collection of fibroblast lines from patients carrying mutations linked to neurological disease. These cell lines have been deposited in the National Institute for Neurological Disorders and Stroke (NINDS) Repository at the Coriell Institute for Medical Research and can be requested by any research group for use in in vitro disease modelling. There are currently 71 mutation-defined cell lines available for request from a wide range of neurological disorders and this collection will be continually expanded. This represents a significant resource that will advance the use of patient cells as disease models by the scientific community.

Details

ISSN :
19326203
Volume :
7
Database :
OpenAIRE
Journal :
PLoS ONE
Accession number :
edsair.doi.dedup.....1ef4f7905f8befb9db610c07e2a2c425
Full Text :
https://doi.org/10.1371/journal.pone.0043099