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Synthesis of γ-butyrolactone fused cyclooctene
- Publication Year :
- 2018
- Publisher :
- Taylor & Francis, 2018.
-
Abstract
- The expeditious route for the synthesis of γ-butyrolactone fused cyclooctene starting from the γ-butyrolactone fused cyclopentane through bicyclo[4.2.1]nonan-9-one is reported. Retro-Dieckmann’s condensation of bicyclo[4.2.1]nonan-9-one in presence of sodium methoxide and methanol furnished γ-butyrolactone fused cyclooctene in good yield. Surprisingly, the stereochemistry of ring-junction of γ-butyrolactone fused cyclooctene is different from the γ-butyrolactone fused cyclopentane, and the position of new ester group, which were confirmed unambiguously by X-ray analysis.
Details
- Database :
- OpenAIRE
- Accession number :
- edsair.doi.dedup.....1f02d32a4c0e6fe7d1ce25f18a167f6d
- Full Text :
- https://doi.org/10.6084/m9.figshare.5766732.v1