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Bioresorbable optical sensor systems for monitoring of intracranial pressure and temperature
- Source :
- Science Advances
- Publication Year :
- 2019
- Publisher :
- American Association for the Advancement of Science, 2019.
-
Abstract
- Bioresorbable optical sensor implants monitor brain pressure and temperature before naturally resorbing into the body.<br />Continuous measurements of pressure and temperature within the intracranial, intraocular, and intravascular spaces provide essential diagnostic information for the treatment of traumatic brain injury, glaucoma, and cardiovascular diseases, respectively. Optical sensors are attractive because of their inherent compatibility with magnetic resonance imaging (MRI). Existing implantable optical components use permanent, nonresorbable materials that must be surgically extracted after use. Bioresorbable alternatives, introduced here, bypass this requirement, thereby eliminating the costs and risks of surgeries. Here, millimeter-scale bioresorbable Fabry-Perot interferometers and two dimensional photonic crystal structures enable precise, continuous measurements of pressure and temperature. Combined mechanical and optical simulations reveal the fundamental sensing mechanisms. In vitro studies and histopathological evaluations quantify the measurement accuracies, operational lifetimes, and biocompatibility of these systems. In vivo demonstrations establish clinically relevant performance attributes. The materials, device designs, and fabrication approaches outlined here establish broad foundational capabilities for diverse classes of bioresorbable optical sensors.
- Subjects :
- musculoskeletal diseases
Diagnostic information
Silicon
genetic structures
Intracranial Pressure
Computer science
Materials Science
02 engineering and technology
Biosensing Techniques
010402 general chemistry
01 natural sciences
Absorbable Implants
Humans
Research Articles
Photonic crystal
Intracranial pressure
Monitoring, Physiologic
Photons
Multidisciplinary
Extramural
Temperature
SciAdv r-articles
Optical Devices
Optics
021001 nanoscience & nanotechnology
musculoskeletal system
Magnetic Resonance Imaging
eye diseases
0104 chemical sciences
Interferometry
sense organs
0210 nano-technology
Biomedical engineering
Research Article
Subjects
Details
- Language :
- English
- ISSN :
- 23752548
- Volume :
- 5
- Issue :
- 7
- Database :
- OpenAIRE
- Journal :
- Science Advances
- Accession number :
- edsair.doi.dedup.....1f0c7b8887f31fe003a86b80084548d2