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Cortical morphometry and neural dysfunction in Huntington’s disease: a review
- Source :
- European Journal of Neurology. 28:1406-1419
- Publication Year :
- 2020
- Publisher :
- Wiley, 2020.
-
Abstract
- Numerous neuroimaging techniques have been used to identify biomarkers of disease progression in Huntington's disease (HD). To date, the earliest and most sensitive of these is caudate volume; however, it is becoming increasingly evident that numerous changes to cortical structures, and their interconnected networks, occur throughout the course of the disease. The mechanisms by which atrophy spreads from the caudate to these cortical regions remains unknown. In this review, the neuroimaging literature specific to T1-weighted and diffusion-weighted magnetic resonance imaging is summarized and new strategies for the investigation of cortical morphometry and the network spread of degeneration in HD are proposed. This new avenue of research may enable further characterization of disease pathology and could add to a suite of biomarker/s of disease progression for patient stratification that will help guide future clinical trials.
- Subjects :
- neuronal dysfunction
Disease
03 medical and health sciences
0302 clinical medicine
Atrophy
Huntington's disease
Neuroimaging
medicine
Humans
030212 general & internal medicine
neuroimaging
medicine.diagnostic_test
business.industry
Disease progression
Brain
Magnetic resonance imaging
medicine.disease
Magnetic Resonance Imaging
Huntington Disease
cortical morphometry
Neurology
Disease Progression
Biomarker (medicine)
Neurology (clinical)
network spread hypothesis
business
Patient stratification
Neuroscience
030217 neurology & neurosurgery
Subjects
Details
- ISSN :
- 14681331 and 13515101
- Volume :
- 28
- Database :
- OpenAIRE
- Journal :
- European Journal of Neurology
- Accession number :
- edsair.doi.dedup.....1f1fe518f001bfb4a28a962a1fdec8e0