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Association Between Toll-Like Receptor Polymorphisms and the Outcome of Liver Transplantation for Chronic Hepatitis C Virus
- Source :
- Transplantation. 84:511-516
- Publication Year :
- 2007
- Publisher :
- Ovid Technologies (Wolters Kluwer Health), 2007.
-
Abstract
- Background. Experimental models suggest that immune cells recognize hepatitis C virus (HCV) through toll-like receptor (TLR)-2 and TLR4. We assessed the association between the single nucleotide polymorphism in genes that encode for these receptors and the outcome of liver transplantation for chronic HCV. Methods. A historical cohort of 92 liver transplant patients with chronic HCV were screened for TLR2 Arg753Gln and TLR4 Asp299Gly and Thr399Ile polymorphisms. The results were correlated with the predefined composite primary outcome of cirrhosis, retransplantation, and death. Statistical analysis was performed using Kaplan-Meier estimation and Cox proportional hazard model. Results. The mean patient age was 49 ± 9 years. Sixty percent were male and 84% were white. Twelve (13%) patients had TLR2 Arg753Gln and 32 (35%) had TLR4 Asp299Gly and/or Thr399Ile polymorphism. During the mean follow-up period of 32 months after liver transplantation, the composite primary outcome occurred in 19 (24%) of 80 patients without TLR2 polymorphism, one (14%) of seven patients with heterozygous TLR2 polymorphism, and in all five (100%) patients with homozygous TLR2 polymorphism (P=0.0007). Time-to-event analysis showed a significant association between homozygous TLR2 polymorphism and the primary outcome (P
- Subjects :
- Adult
Graft Rejection
Male
medicine.medical_specialty
Cirrhosis
Hepacivirus
medicine.medical_treatment
Hepatitis C virus
Single-nucleotide polymorphism
Kaplan-Meier Estimate
Liver transplantation
medicine.disease_cause
Polymorphism, Single Nucleotide
Gastroenterology
Cohort Studies
Flaviviridae
Internal medicine
Genotype
medicine
Humans
Proportional Hazards Models
Transplantation
biology
Proportional hazards model
Hepatitis C, Chronic
Middle Aged
medicine.disease
biology.organism_classification
Toll-Like Receptor 2
Liver Transplantation
Toll-Like Receptor 4
Treatment Outcome
Liver
Immunology
Female
Subjects
Details
- ISSN :
- 00411337
- Volume :
- 84
- Database :
- OpenAIRE
- Journal :
- Transplantation
- Accession number :
- edsair.doi.dedup.....1f32ec7df4deeaa4ddc9a4d6a24cbde4
- Full Text :
- https://doi.org/10.1097/01.tp.0000276960.35313.bf