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Parkinson's disease: in vivo assessment of disease progression using positron emission tomography
- Source :
- Molecular Brain Research. 134:24-33
- Publication Year :
- 2005
- Publisher :
- Elsevier BV, 2005.
-
Abstract
- Over the past two decades, positron emission tomography (PET) has provided valuable insights into the mechanisms of nigrostriatal degeneration in Parkinson's disease (PD). Furthermore, it allows the in vivo assessment of disease progression and the evaluation of treatment interventions. In this review, we shall discuss some of the issues and concerns that arise with the use of PET as a surrogate marker of disease progression in Parkinson's disease.
- Subjects :
- Pathology
medicine.medical_specialty
Parkinson's disease
Dopamine
Models, Neurological
Nerve Tissue Proteins
Disease
Biology
Central nervous system disease
Cellular and Molecular Neuroscience
Degenerative disease
In vivo
Vesicular Biogenic Amine Transport Proteins
medicine
Animals
Humans
Molecular Biology
Dopamine Plasma Membrane Transport Proteins
Membrane Glycoproteins
medicine.diagnostic_test
Surrogate endpoint
Disease progression
Brain
Membrane Transport Proteins
Parkinson Disease
medicine.disease
Positron emission tomography
Positron-Emission Tomography
Disease Progression
Neuroscience
Subjects
Details
- ISSN :
- 0169328X
- Volume :
- 134
- Database :
- OpenAIRE
- Journal :
- Molecular Brain Research
- Accession number :
- edsair.doi.dedup.....1f4505a9fa70ca87e5135ad45b433655