Back to Search
Start Over
Paternal safety of the use of mycophenolic acid in kidney transplant recipients. Results of the EMVARON study
- Source :
- Clinical Transplantation. 35
- Publication Year :
- 2021
- Publisher :
- Wiley, 2021.
-
Abstract
- Background The use of mycophenolic acid (MPA) in women during pregnancy causes an increase in miscarriages and birth defects with a typical embryopathy profile. Although epidemiological data does not suggest a greater risk among the offspring of male kidney transplant recipients, the European Medicines Agency and The Spanish Agency of Medicines and Medical Devices introduced the recommendation of using contraceptive methods. Methods We conducted a national retrospective study in 15 Spanish Kidney Transplant Centers to evaluate the frequency of miscarriages and birth defects between the offspring from male kidney transplants recipients. We included 151 males who had fathered 239 offspring, 225 under MPA and 14 without MPA. Results The results of our study showed an incidence of miscarriages in the MPA group of 9.8%, and of birth defects of 4%. Conclusions We observed an incidence of miscarriages between the offspring fathered by kidney transplant males under MPA lower than the general population. The incidence of birth defects was similar to the incidence described in other studies and the fact that we did not find the typical embryopathy profile makes it difficult to associate them to the use of MPA. Because of that, we urge the European and Spanish Agencies to reconsider their recommendations for males.
- Subjects :
- Male
medicine.medical_specialty
Offspring
Population
Kidney transplant
Mycophenolic acid
Pregnancy
Epidemiology
medicine
Humans
education
Retrospective Studies
Transplantation
education.field_of_study
business.industry
Obstetrics
Incidence (epidemiology)
Retrospective cohort study
Mycophenolic Acid
medicine.disease
Kidney Transplantation
Transplant Recipients
Female
Tablets, Enteric-Coated
business
Immunosuppressive Agents
medicine.drug
Subjects
Details
- ISSN :
- 13990012 and 09020063
- Volume :
- 35
- Database :
- OpenAIRE
- Journal :
- Clinical Transplantation
- Accession number :
- edsair.doi.dedup.....1f4963c5e69f32745bf3afc360649d1f