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Characteristics and Survival Outcomes of Hepatocellular Carcinoma Developed after HCV SVR
- Source :
- Cancers, Cancers, Vol 13, Iss 3455, p 3455 (2021), Volume 13, Issue 14, Web of Science
- Publication Year :
- 2021
- Publisher :
- MDPI, 2021.
-
Abstract
- The clinical presentation and survival of hepatocellular carcinoma (HCC) after hepatitis C virus (HCV) eradication as compared to HCC in viremic patients are not well characterized. We aimed to investigate the characteristics and survival between HCV patients with and without viremia at HCC diagnosis.: We retrospectively analyzed overall survival outcomes in 1389 HCV-related HCC patients, including 301 with HCC developed after HCV eradication (post-SVR HCC) and 1088 with HCV viremia at HCC diagnosis (viremic HCC). We also evaluated overall survival in the two groups using propensity score-matching methods.: At HCC diagnosis, post-SVR HCC patients were older, less obese, less likely cirrhotic, with better liver function, lower alfa-fetoprotein levels, earlier BCLC stages, and higher rate of treatment with surgery. Overall, post-SVR HCC patients had higher median survival than viremic patients (153.3 vs. 55.6 months, p &lt<br />0.01), but post-SVR HCC was not independently associated with survival on multivariate analysis (adjusted HR: 1.05, 95% CI: 0.76–1.47). However, on sub-analysis, viremic HCC patients who subsequently received anti-viral treatment and achieved SVR had higher median survival than post-SVR HCC patients (p &lt<br />0.01). Viremic HCC with subsequent SVR was also significantly associated with lower mortality as compared to post-SVR HCC (adjusted HR: 0.18, 95% CI: 0.11–0.29). In addition, we observed similar findings in our analysis of the propensity score-matched cohorts.: The advantages in clinical and tumor characters at HCC diagnosis determined the better overall survival of post-SVR HCC patients<br />however, HCV eradication after HCC development was also associated with improved survival.
- Subjects :
- hepatitis C virus
Cancer Research
medicine.medical_specialty
Multivariate analysis
Hepatitis C virus
Improved survival
Viremia
medicine.disease_cause
Gastroenterology
survival
Article
03 medical and health sciences
0302 clinical medicine
Internal medicine
Medicine
chronic hepatitis C
neoplasms
RC254-282
viremia
business.industry
Neoplasms. Tumors. Oncology. Including cancer and carcinogens
virus diseases
hepatocellular carcinoma
medicine.disease
digestive system diseases
Oncology
030220 oncology & carcinogenesis
Hepatocellular carcinoma
030211 gastroenterology & hepatology
Liver function
business
Lower mortality
Median survival
Subjects
Details
- Language :
- English
- ISSN :
- 20726694
- Volume :
- 13
- Issue :
- 14
- Database :
- OpenAIRE
- Journal :
- Cancers
- Accession number :
- edsair.doi.dedup.....1f911b10a3b674f65c9e244150a76154