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Self-assembly of palmitoyl lipopeptides used in skin care products
- Source :
- Langmuir : the ACS journal of surfaces and colloids. 29(29)
- Publication Year :
- 2013
-
Abstract
- The self-assembly of three cosmetically active peptide amphiphiles C16-GHK, C16-KT, and C16-KTTKS (C16 denotes a hexadecyl, palmitoyl chain) used in commercial skin care products is examined. A range of spectroscopic, microscopic, and X-ray scattering methods is used to probe the secondary structure, aggregate morphology, and the nanostructure. Peptide amphiphile (PA) C16-KTTKS forms flat tapes and extended fibrillar structures with high β-sheet content. In contrast, C16-KT and C16-GHK exhibit crystal-like aggregates with, in the case of the latter PA, lower β-sheet content. All three PA samples show spacings from bilayer structures in small-angle X-ray scattering profiles, and all three have similar critical aggregation concentrations, this being governed by the lipid chain length. However, only C16-KTTKS is stained by Congo red, a diagnostic dye used to detect amyloid formation, and this PA also shows a highly aligned cross-β X-ray diffraction pattern consistent with the high β-sheet content in the self-assembled aggregates. These findings may provide important insights relevant to the role of self-assembled aggregates on the reported collagen-stimulating properties of these PAs.
- Subjects :
- Nanostructure
Palmitic Acid
Peptide
Cosmetics
chemistry.chemical_compound
Lipopeptides
Amphiphile
Electrochemistry
Peptide amphiphile
Organic chemistry
General Materials Science
Amino Acid Sequence
Protein secondary structure
Spectroscopy
chemistry.chemical_classification
Bilayer
food and beverages
Surfaces and Interfaces
Condensed Matter Physics
Skin Care
Congo red
Crystallography
chemistry
lipids (amino acids, peptides, and proteins)
Self-assembly
Hydrophobic and Hydrophilic Interactions
Subjects
Details
- ISSN :
- 15205827
- Volume :
- 29
- Issue :
- 29
- Database :
- OpenAIRE
- Journal :
- Langmuir : the ACS journal of surfaces and colloids
- Accession number :
- edsair.doi.dedup.....1fb84c3e206eb912f3a4c9b9d98c3582